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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IRAK4
All Species:
10.61
Human Site:
S423
Identified Species:
21.21
UniProt:
Q9NWZ3
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NWZ3
NP_001107654.1
460
51530
S423
K
K
M
N
D
A
D
S
T
S
V
E
A
M
Y
Chimpanzee
Pan troglodytes
XP_001166114
460
51588
S423
K
K
M
N
D
A
D
S
T
S
V
E
T
M
Y
Rhesus Macaque
Macaca mulatta
NP_001129573
460
51601
S423
K
K
M
N
D
A
D
S
T
S
V
E
A
M
Y
Dog
Lupus familis
XP_543727
460
51521
P423
P
K
M
N
D
T
D
P
T
S
I
E
T
M
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8R4K2
459
50853
P423
E
K
M
S
D
A
D
P
A
S
V
E
A
M
Y
Rat
Rattus norvegicus
NP_001100261
461
51050
P425
E
K
M
S
D
A
D
P
A
S
V
E
A
M
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001521647
280
31332
G253
E
N
L
V
E
L
I
G
F
S
S
D
G
D
D
Chicken
Gallus gallus
NP_001025909
373
40585
I346
A
Q
G
T
A
N
G
I
N
F
L
H
D
N
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_956457
382
41751
A355
F
G
L
T
R
S
A
A
A
G
A
A
G
G
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784716
406
45182
A376
A
Q
V
M
Y
D
L
A
S
R
C
T
E
Q
K
Poplar Tree
Populus trichocarpa
XP_002322185
562
63055
M503
N
M
K
G
S
Y
P
M
D
E
V
Y
K
M
A
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_198715
880
97935
S769
D
L
T
A
D
I
T
S
T
S
M
E
K
F
C
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.1
98.6
92.8
N.A.
83.9
84.3
N.A.
45.2
47.3
N.A.
39.1
N.A.
N.A.
N.A.
N.A.
33.9
Protein Similarity:
100
99.5
99.1
96.3
N.A.
90.8
91.9
N.A.
51.9
58.2
N.A.
54.7
N.A.
N.A.
N.A.
N.A.
51
P-Site Identity:
100
93.3
100
66.6
N.A.
73.3
73.3
N.A.
6.6
0
N.A.
0
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
93.3
100
73.3
N.A.
86.6
86.6
N.A.
33.3
13.3
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
26.6
Percent
Protein Identity:
28.1
N.A.
N.A.
21.5
N.A.
N.A.
Protein Similarity:
47.5
N.A.
N.A.
34.4
N.A.
N.A.
P-Site Identity:
13.3
N.A.
N.A.
33.3
N.A.
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
17
0
0
9
9
42
9
17
25
0
9
9
34
0
9
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
9
% C
% Asp:
9
0
0
0
59
9
50
0
9
0
0
9
9
9
9
% D
% Glu:
25
0
0
0
9
0
0
0
0
9
0
59
9
0
0
% E
% Phe:
9
0
0
0
0
0
0
0
9
9
0
0
0
9
9
% F
% Gly:
0
9
9
9
0
0
9
9
0
9
0
0
17
9
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
0
% H
% Ile:
0
0
0
0
0
9
9
9
0
0
9
0
0
0
0
% I
% Lys:
25
50
9
0
0
0
0
0
0
0
0
0
17
0
9
% K
% Leu:
0
9
17
0
0
9
9
0
0
0
9
0
0
0
0
% L
% Met:
0
9
50
9
0
0
0
9
0
0
9
0
0
59
0
% M
% Asn:
9
9
0
34
0
9
0
0
9
0
0
0
0
9
9
% N
% Pro:
9
0
0
0
0
0
9
25
0
0
0
0
0
0
0
% P
% Gln:
0
17
0
0
0
0
0
0
0
0
0
0
0
9
0
% Q
% Arg:
0
0
0
0
9
0
0
0
0
9
0
0
0
0
0
% R
% Ser:
0
0
0
17
9
9
0
34
9
67
9
0
0
0
0
% S
% Thr:
0
0
9
17
0
9
9
0
42
0
0
9
17
0
0
% T
% Val:
0
0
9
9
0
0
0
0
0
0
50
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
9
9
0
0
0
0
0
9
0
0
50
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _