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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD4
All Species:
33.64
Human Site:
Y254
Identified Species:
61.67
UniProt:
Q9NVD3
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NVD3
NP_001007260.1
440
50416
Y254
F
N
E
E
T
H
S
Y
E
I
R
T
T
S
R
Chimpanzee
Pan troglodytes
XP_001168912
440
50497
Y254
F
N
E
E
T
H
S
Y
E
I
R
T
T
S
R
Rhesus Macaque
Macaca mulatta
XP_001085715
440
50622
Y254
F
N
E
E
T
H
S
Y
E
I
R
T
T
S
R
Dog
Lupus familis
XP_544872
476
54805
Y290
F
N
E
E
T
R
C
Y
E
I
R
T
A
S
N
Cat
Felis silvestris
Mouse
Mus musculus
P58467
439
49818
Y253
F
N
E
K
T
R
C
Y
E
I
R
T
A
S
R
Rat
Rattus norvegicus
NP_001107219
439
49656
Y253
F
N
E
K
T
R
C
Y
E
I
R
T
A
S
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512617
707
77741
Y254
F
N
K
E
T
R
C
Y
E
I
R
T
A
S
R
Chicken
Gallus gallus
NP_001025965
439
50536
Y253
F
N
E
Q
S
R
N
Y
E
I
Q
T
N
S
Q
Frog
Xenopus laevis
NP_001079674
456
52090
Y254
F
S
K
D
R
R
C
Y
E
I
R
T
N
S
G
Zebra Danio
Brachydanio rerio
NP_001039027
440
51126
Y255
F
N
K
E
T
R
C
Y
E
I
R
S
V
N
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_490849
401
46372
V216
E
K
R
N
G
R
Y
V
V
Q
A
K
R
Q
I
Sea Urchin
Strong. purpuratus
XP_001201449
320
36303
P135
S
G
C
E
A
F
D
P
K
A
S
D
D
F
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03942
479
55931
E294
L
S
P
Q
L
R
S
E
G
E
N
I
I
G
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
97.7
77
N.A.
77
75.4
N.A.
42.2
63.4
52.8
48.1
N.A.
N.A.
N.A.
24.7
23.8
Protein Similarity:
100
99.7
98.6
84.2
N.A.
86.8
85.9
N.A.
50.6
78.4
70.6
65.2
N.A.
N.A.
N.A.
44.3
39.5
P-Site Identity:
100
100
100
73.3
N.A.
73.3
73.3
N.A.
73.3
53.3
46.6
53.3
N.A.
N.A.
N.A.
0
6.6
P-Site Similarity:
100
100
100
73.3
N.A.
80
80
N.A.
80
86.6
66.6
73.3
N.A.
N.A.
N.A.
0
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
38
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
0
0
8
8
0
31
0
8
% A
% Cys:
0
0
8
0
0
0
47
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
0
0
8
0
0
0
0
8
8
0
0
% D
% Glu:
8
0
54
54
0
0
0
8
77
8
0
0
0
0
0
% E
% Phe:
77
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% F
% Gly:
0
8
0
0
8
0
0
0
8
0
0
0
0
8
16
% G
% His:
0
0
0
0
0
24
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
77
0
8
8
0
16
% I
% Lys:
0
8
24
16
0
0
0
0
8
0
0
8
0
0
0
% K
% Leu:
8
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
70
0
8
0
0
8
0
0
0
8
0
16
8
8
% N
% Pro:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
16
0
0
0
0
0
8
8
0
0
8
8
% Q
% Arg:
0
0
8
0
8
70
0
0
0
0
70
0
8
0
47
% R
% Ser:
8
16
0
0
8
0
31
0
0
0
8
8
0
70
0
% S
% Thr:
0
0
0
0
62
0
0
0
0
0
0
70
24
0
0
% T
% Val:
0
0
0
0
0
0
0
8
8
0
0
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
77
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _