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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD4
All Species:
13.75
Human Site:
T440
Identified Species:
25.21
UniProt:
Q9NVD3
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NVD3
NP_001007260.1
440
50416
T440
H
S
L
Q
T
A
F
T
_
_
_
_
_
_
_
Chimpanzee
Pan troglodytes
XP_001168912
440
50497
T440
H
S
L
Q
T
A
F
T
_
_
_
_
_
_
_
Rhesus Macaque
Macaca mulatta
XP_001085715
440
50622
T440
H
S
L
Q
T
A
F
T
_
_
_
_
_
_
_
Dog
Lupus familis
XP_544872
476
54805
R476
N
S
L
Q
T
P
F
R
_
_
_
_
_
_
_
Cat
Felis silvestris
Mouse
Mus musculus
P58467
439
49818
S439
S
G
L
L
A
P
F
S
_
_
_
_
_
_
_
Rat
Rattus norvegicus
NP_001107219
439
49656
S439
S
S
S
L
A
P
L
S
_
_
_
_
_
_
_
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512617
707
77741
P440
E
D
L
P
A
G
T
P
H
H
L
V
L
G
H
Chicken
Gallus gallus
NP_001025965
439
50536
I439
C
N
L
N
V
T
T
I
_
_
_
_
_
_
_
Frog
Xenopus laevis
NP_001079674
456
52090
S440
N
L
L
Q
N
E
P
S
A
G
P
T
G
A
A
Zebra Danio
Brachydanio rerio
NP_001039027
440
51126
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_490849
401
46372
Sea Urchin
Strong. purpuratus
XP_001201449
320
36303
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03942
479
55931
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
97.7
77
N.A.
77
75.4
N.A.
42.2
63.4
52.8
48.1
N.A.
N.A.
N.A.
24.7
23.8
Protein Similarity:
100
99.7
98.6
84.2
N.A.
86.8
85.9
N.A.
50.6
78.4
70.6
65.2
N.A.
N.A.
N.A.
44.3
39.5
P-Site Identity:
100
100
100
62.5
N.A.
25
12.5
N.A.
6.6
12.5
13.3
0
N.A.
N.A.
N.A.
0
0
P-Site Similarity:
100
100
100
75
N.A.
37.5
25
N.A.
13.3
25
40
0
N.A.
N.A.
N.A.
0
0
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
38
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
24
24
0
0
8
0
0
0
0
8
8
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
39
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
8
0
0
0
8
0
0
8
8
0
% G
% His:
24
0
0
0
0
0
0
0
8
8
0
0
0
0
8
% H
% Ile:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
62
16
0
0
8
0
0
0
8
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
16
8
0
8
8
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
24
8
8
0
0
8
0
0
0
0
% P
% Gln:
0
0
0
39
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% R
% Ser:
16
39
8
0
0
0
0
24
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
31
8
16
24
0
0
0
8
0
0
0
% T
% Val:
0
0
0
0
8
0
0
0
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
54
54
54
54
54
54
54
% _