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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SETD4
All Species:
34.55
Human Site:
S238
Identified Species:
63.33
UniProt:
Q9NVD3
Number Species:
12
Phosphosite Substitution
Charge Score:
0.17
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NVD3
NP_001007260.1
440
50416
S238
Y
L
D
L
L
N
H
S
P
H
V
Q
V
K
A
Chimpanzee
Pan troglodytes
XP_001168912
440
50497
S238
Y
L
D
L
L
N
H
S
P
H
V
Q
V
K
A
Rhesus Macaque
Macaca mulatta
XP_001085715
440
50622
S238
Y
L
D
L
L
N
H
S
P
R
V
Q
V
K
A
Dog
Lupus familis
XP_544872
476
54805
S274
Y
L
D
L
L
N
H
S
P
E
V
Q
V
K
G
Cat
Felis silvestris
Mouse
Mus musculus
P58467
439
49818
S237
F
L
D
L
L
N
H
S
P
H
V
Q
V
K
A
Rat
Rattus norvegicus
NP_001107219
439
49656
S237
F
L
D
L
L
N
H
S
P
H
V
Q
V
K
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512617
707
77741
S238
Y
L
D
L
L
N
H
S
P
G
A
Q
V
E
A
Chicken
Gallus gallus
NP_001025965
439
50536
S237
Y
L
D
L
L
N
H
S
P
N
V
Q
V
K
A
Frog
Xenopus laevis
NP_001079674
456
52090
S238
Y
L
D
L
L
N
H
S
P
E
V
Q
V
E
A
Zebra Danio
Brachydanio rerio
NP_001039027
440
51126
C239
Y
L
D
L
L
N
H
C
P
N
V
Q
V
E
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
NP_490849
401
46372
E200
D
M
L
N
H
D
P
E
K
Y
Q
G
L
A
L
Sea Urchin
Strong. purpuratus
XP_001201449
320
36303
N119
V
W
A
W
F
V
I
N
S
R
S
V
Y
I
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q03942
479
55931
E278
D
F
M
N
H
I
C
E
S
D
L
H
C
Y
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
97.7
77
N.A.
77
75.4
N.A.
42.2
63.4
52.8
48.1
N.A.
N.A.
N.A.
24.7
23.8
Protein Similarity:
100
99.7
98.6
84.2
N.A.
86.8
85.9
N.A.
50.6
78.4
70.6
65.2
N.A.
N.A.
N.A.
44.3
39.5
P-Site Identity:
100
100
93.3
86.6
N.A.
93.3
93.3
N.A.
80
93.3
86.6
80
N.A.
N.A.
N.A.
0
0
P-Site Similarity:
100
100
93.3
86.6
N.A.
100
100
N.A.
86.6
100
93.3
93.3
N.A.
N.A.
N.A.
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
38
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
0
0
0
0
0
8
0
0
8
70
% A
% Cys:
0
0
0
0
0
0
8
8
0
0
0
0
8
0
0
% C
% Asp:
16
0
77
0
0
8
0
0
0
8
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
0
16
0
16
0
0
0
24
8
% E
% Phe:
16
8
0
0
8
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
8
0
8
0
0
8
% G
% His:
0
0
0
0
16
0
77
0
0
31
0
8
0
0
0
% H
% Ile:
0
0
0
0
0
8
8
0
0
0
0
0
0
8
0
% I
% Lys:
0
0
0
0
0
0
0
0
8
0
0
0
0
54
0
% K
% Leu:
0
77
8
77
77
0
0
0
0
0
8
0
8
0
8
% L
% Met:
0
8
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
16
0
77
0
8
0
16
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
0
77
0
0
0
0
0
8
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
8
77
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
16
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
70
16
0
8
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
8
0
0
0
0
8
0
0
0
0
70
8
77
0
0
% V
% Trp:
0
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
62
0
0
0
0
0
0
0
0
8
0
0
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _