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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMC4
All Species:
23.33
Human Site:
S149
Identified Species:
32.08
UniProt:
Q9NTJ3
Number Species:
16
Phosphosite Substitution
Charge Score:
0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NTJ3
NP_001002800.1
1288
147182
S149
L
S
V
L
I
H
N
S
D
E
H
K
D
I
Q
Chimpanzee
Pan troglodytes
XP_001157958
1288
147223
S149
L
S
V
L
I
H
N
S
D
E
H
K
D
I
Q
Rhesus Macaque
Macaca mulatta
XP_001099428
1287
147121
D149
S
V
L
I
H
N
S
D
E
H
K
D
I
Q
S
Dog
Lupus familis
XP_535848
1288
147094
S149
L
S
V
L
I
H
N
S
D
E
H
K
D
I
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8CG47
1286
146876
E149
V
L
I
H
N
S
D
E
H
K
D
I
Q
S
C
Rat
Rattus norvegicus
Q9Z1M9
1233
143186
K149
S
I
A
M
K
N
P
K
E
R
T
A
L
F
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510551
1069
122201
K68
V
K
M
V
E
K
E
K
D
S
L
E
G
E
K
Chicken
Gallus gallus
NP_989849
1274
145838
S166
T
A
Y
R
D
N
S
S
V
Y
H
I
N
G
K
Frog
Xenopus laevis
P50532
1290
146971
V149
N
S
D
E
H
K
D
V
Q
S
C
T
V
E
V
Zebra Danio
Brachydanio rerio
NP_775360
1289
145687
D149
S
V
L
I
H
S
S
D
G
H
P
D
I
Q
S
Tiger Blowfish
Takifugu rubipres
NP_001027927
1326
150958
D150
H
S
S
D
K
H
K
D
V
E
S
C
T
V
E
Fruit Fly
Dros. melanogaster
Q9VJE5
1690
189046
N164
L
D
E
P
N
G
K
N
D
G
C
V
S
G
K
Honey Bee
Apis mellifera
XP_396862
1282
148175
S149
E
Y
D
I
V
P
N
S
E
I
V
I
S
R
T
Nematode Worm
Caenorhab. elegans
Q20060
1549
176553
S157
V
S
N
L
I
H
K
S
A
G
R
N
P
D
K
Sea Urchin
Strong. purpuratus
XP_797583
1289
146235
S168
L
S
V
L
I
H
K
S
E
N
H
K
D
L
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FJL0
1241
141112
T149
N
E
R
S
S
N
F
T
E
V
T
K
K
L
K
Baker's Yeast
Sacchar. cerevisiae
Q12267
1418
162171
S221
L
S
D
L
I
H
K
S
E
A
F
P
S
L
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
98.3
94
N.A.
89.5
24
N.A.
67.8
75.3
76.9
67.9
66.7
20.1
45.9
29.9
48.1
Protein Similarity:
100
99.6
98.9
96.5
N.A.
94.8
47.5
N.A.
75
86.3
87.5
83.5
81.2
40.2
63.9
47.5
65.4
P-Site Identity:
100
100
0
100
N.A.
0
0
N.A.
6.6
13.3
6.6
0
20
13.3
13.3
33.3
66.6
P-Site Similarity:
100
100
33.3
100
N.A.
26.6
26.6
N.A.
40
46.6
13.3
20
33.3
26.6
33.3
46.6
86.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
41.3
35.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
58.7
55.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
46.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
6
6
0
0
0
0
0
6
6
0
6
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
12
6
0
0
6
% C
% Asp:
0
6
18
6
6
0
12
18
30
0
6
12
24
6
0
% D
% Glu:
6
6
6
6
6
0
6
6
36
24
0
6
0
12
12
% E
% Phe:
0
0
0
0
0
0
6
0
0
0
6
0
0
6
0
% F
% Gly:
0
0
0
0
0
6
0
0
6
12
0
0
6
12
0
% G
% His:
6
0
0
6
18
42
0
0
6
12
30
0
0
0
0
% H
% Ile:
0
6
6
18
36
0
0
0
0
6
0
18
12
18
0
% I
% Lys:
0
6
0
0
12
12
30
12
0
6
6
30
6
0
36
% K
% Leu:
36
6
12
36
0
0
0
0
0
0
6
0
6
18
0
% L
% Met:
0
0
6
6
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
12
0
6
0
12
24
24
6
0
6
0
6
6
0
0
% N
% Pro:
0
0
0
6
0
6
6
0
0
0
6
6
6
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
6
0
0
0
6
12
24
% Q
% Arg:
0
0
6
6
0
0
0
0
0
6
6
0
0
6
0
% R
% Ser:
18
48
6
6
6
12
18
48
0
12
6
0
18
6
12
% S
% Thr:
6
0
0
0
0
0
0
6
0
0
12
6
6
0
6
% T
% Val:
18
12
24
6
6
0
0
6
12
6
6
6
6
6
6
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
6
6
0
0
0
0
0
0
6
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _