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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMYD2
All Species:
34.85
Human Site:
S125
Identified Species:
58.97
UniProt:
Q9NRG4
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRG4
NP_064582.2
433
49688
S125
I
H
P
E
R
T
P
S
E
K
L
L
A
V
K
Chimpanzee
Pan troglodytes
XP_514316
454
52196
T150
G
L
R
Q
L
V
M
T
F
Q
H
F
M
R
E
Rhesus Macaque
Macaca mulatta
XP_001106482
433
49665
S125
I
H
P
E
R
T
P
S
E
K
L
L
A
V
K
Dog
Lupus familis
XP_537149
432
49720
S124
I
H
P
E
R
T
P
S
E
K
L
L
A
V
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8R5A0
433
49548
S125
I
H
P
E
R
T
P
S
E
K
L
L
A
V
R
Rat
Rattus norvegicus
Q7M6Z3
433
49630
S125
M
H
P
E
R
T
P
S
E
K
L
L
A
V
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510161
439
49949
S131
A
H
P
E
R
T
P
S
E
K
L
L
A
V
K
Chicken
Gallus gallus
XP_419420
436
49919
S128
I
H
P
E
R
T
Q
S
E
K
L
L
A
V
K
Frog
Xenopus laevis
NP_001085986
430
49101
S123
T
Q
T
E
R
T
A
S
E
R
F
M
S
V
K
Zebra Danio
Brachydanio rerio
NP_001013568
435
50045
S125
H
Q
T
E
R
T
P
S
E
R
V
L
T
L
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O46040
462
52138
H170
L
T
A
V
R
V
F
H
L
G
K
E
Q
R
H
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09415
429
48527
D119
E
H
H
P
S
S
Y
D
A
D
E
E
S
F
V
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001131420
482
54569
S136
N
E
K
V
I
P
S
S
S
I
D
N
Y
N
L
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q7XJS0
480
54809
T132
N
E
K
V
L
P
I
T
T
T
D
N
Y
S
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
32.8
99
92.6
N.A.
93.3
93.5
N.A.
80.6
85.5
78.7
75.4
N.A.
20.5
N.A.
22.6
N.A.
Protein Similarity:
100
53.7
99
94.2
N.A.
96.5
97
N.A.
85.8
94
88.2
87.3
N.A.
35
N.A.
42.7
N.A.
P-Site Identity:
100
0
100
100
N.A.
93.3
86.6
N.A.
93.3
93.3
46.6
46.6
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
26.6
100
100
N.A.
100
100
N.A.
93.3
93.3
66.6
73.3
N.A.
13.3
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
29.8
N.A.
25.8
N.A.
N.A.
Protein Similarity:
N.A.
46.4
N.A.
45.8
N.A.
N.A.
P-Site Identity:
N.A.
6.6
N.A.
0
N.A.
N.A.
P-Site Similarity:
N.A.
6.6
N.A.
6.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
8
0
0
0
8
0
8
0
0
0
50
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
8
0
8
15
0
0
0
0
% D
% Glu:
8
15
0
65
0
0
0
0
65
0
8
15
0
0
8
% E
% Phe:
0
0
0
0
0
0
8
0
8
0
8
8
0
8
0
% F
% Gly:
8
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% G
% His:
8
58
8
0
0
0
0
8
0
0
8
0
0
0
8
% H
% Ile:
36
0
0
0
8
0
8
0
0
8
0
0
0
0
0
% I
% Lys:
0
0
15
0
0
0
0
0
0
50
8
0
0
0
43
% K
% Leu:
8
8
0
0
15
0
0
0
8
0
50
58
0
8
15
% L
% Met:
8
0
0
0
0
0
8
0
0
0
0
8
8
0
0
% M
% Asn:
15
0
0
0
0
0
0
0
0
0
0
15
0
8
0
% N
% Pro:
0
0
50
8
0
15
50
0
0
0
0
0
0
0
0
% P
% Gln:
0
15
0
8
0
0
8
0
0
8
0
0
8
0
0
% Q
% Arg:
0
0
8
0
72
0
0
0
0
15
0
0
0
15
22
% R
% Ser:
0
0
0
0
8
8
8
72
8
0
0
0
15
8
0
% S
% Thr:
8
8
15
0
0
65
0
15
8
8
0
0
8
0
0
% T
% Val:
0
0
0
22
0
15
0
0
0
0
8
0
0
58
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
0
0
0
0
0
15
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _