KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinector
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
POLE3
All Species:
15.76
Human Site:
S116
Identified Species:
28.89
UniProt:
Q9NRF9
Number Species:
12
Phosphosite Substitution
Charge Score:
0.25
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRF9
NP_059139.3
147
16860
S116
D
K
D
K
K
T
D
S
E
E
Q
D
K
S
R
Chimpanzee
Pan troglodytes
XP_001153197
176
19753
S145
D
K
D
K
K
T
D
S
E
E
Q
D
K
S
R
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_855374
283
30359
A252
D
K
D
K
K
T
D
A
E
E
Q
D
K
G
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9JKP7
145
16611
E116
D
K
D
K
K
D
S
E
E
Q
D
K
S
R
E
Rat
Rattus norvegicus
Q642A5
145
16656
E116
D
K
D
K
K
D
C
E
E
Q
D
K
S
R
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
NP_001020525
143
16341
D116
K
A
D
S
E
E
Q
D
K
S
R
E
D
D
N
Frog
Xenopus laevis
NP_001084468
147
16813
S116
D
K
E
K
K
A
D
S
E
D
Q
D
K
S
R
Zebra Danio
Brachydanio rerio
NP_957095
148
16781
T116
D
K
E
K
K
N
G
T
D
E
N
D
K
S
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_476646
128
13825
E113
K
K
D
S
N
T
A
E
N
A
N
A
S
A
T
Honey Bee
Apis mellifera
XP_001122640
129
14452
I116
Q
K
K
D
E
D
D
I
I
E
E
E
D
G
G
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_785187
199
21870
S116
N
K
E
E
Q
D
T
S
K
E
E
E
E
G
E
Poplar Tree
Populus trichocarpa
XP_002312821
145
15950
G125
V
Q
K
K
R
K
T
G
G
P
S
K
K
S
G
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9FGJ3
190
20511
R138
G
E
V
G
E
H
Q
R
D
A
V
G
D
G
G
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
83.5
N.A.
51.2
N.A.
91.1
95.9
N.A.
N.A.
88.4
84.3
75
N.A.
42.8
52.3
N.A.
48.7
Protein Similarity:
100
83.5
N.A.
51.5
N.A.
97.9
97.9
N.A.
N.A.
94.5
97.2
89.1
N.A.
57.1
68.7
N.A.
62.3
P-Site Identity:
100
100
N.A.
86.6
N.A.
40
40
N.A.
N.A.
6.6
80
60
N.A.
20
20
N.A.
20
P-Site Similarity:
100
100
N.A.
93.3
N.A.
46.6
46.6
N.A.
N.A.
33.3
93.3
80
N.A.
26.6
40
N.A.
73.3
Percent
Protein Identity:
32.6
N.A.
N.A.
21.5
N.A.
N.A.
Protein Similarity:
55.1
N.A.
N.A.
40.5
N.A.
N.A.
P-Site Identity:
20
N.A.
N.A.
0
N.A.
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
8
8
8
0
16
0
8
0
8
0
% A
% Cys:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% C
% Asp:
54
0
54
8
0
31
39
8
16
8
16
39
24
8
0
% D
% Glu:
0
8
24
8
24
8
0
24
47
47
16
24
8
0
24
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
8
0
0
8
8
8
0
0
8
0
31
24
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
8
8
0
0
0
0
0
0
% I
% Lys:
16
77
16
62
54
8
0
0
16
0
0
24
47
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
8
8
0
0
8
0
16
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% P
% Gln:
8
8
0
0
8
0
16
0
0
16
31
0
0
0
0
% Q
% Arg:
0
0
0
0
8
0
0
8
0
0
8
0
0
16
39
% R
% Ser:
0
0
0
16
0
0
8
31
0
8
8
0
24
39
0
% S
% Thr:
0
0
0
0
0
31
16
8
0
0
0
0
0
0
8
% T
% Val:
8
0
8
0
0
0
0
0
0
0
8
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _