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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPHK2
All Species:
12.42
Human Site:
T389
Identified Species:
27.33
UniProt:
Q9NRA0
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRA0
NP_064511.2
654
69217
T389
T
V
E
P
A
S
P
T
P
A
H
S
L
P
R
Chimpanzee
Pan troglodytes
XP_001171276
652
69465
T389
T
V
E
P
A
S
P
T
P
A
H
S
L
P
R
Rhesus Macaque
Macaca mulatta
XP_001113908
653
69532
T388
T
V
E
P
T
S
P
T
P
V
H
S
L
P
R
Dog
Lupus familis
XP_541516
663
70246
T394
A
V
E
P
A
S
P
T
P
A
H
G
L
P
R
Cat
Felis silvestris
Mouse
Mus musculus
Q9JIA7
617
65600
I354
T
T
E
P
A
L
P
I
P
G
H
S
L
P
R
Rat
Rattus norvegicus
Q91V26
383
42400
C138
N
E
D
L
L
I
N
C
T
L
L
L
C
C
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001088560
509
55981
L264
Q
A
V
G
N
K
L
L
N
N
C
T
F
I
L
Zebra Danio
Brachydanio rerio
Q7ZW00
422
47526
H177
V
S
D
N
K
V
Q
H
I
T
S
A
T
L
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647762
661
73852
R407
N
L
R
T
Y
N
G
R
I
S
Y
L
L
T
D
Honey Bee
Apis mellifera
XP_394823
620
69588
K371
V
S
Y
L
P
C
D
K
V
P
S
V
E
S
L
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LRB0
763
83573
K450
Q
K
E
D
A
E
G
K
I
R
L
E
K
E
A
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96
96.6
90.8
N.A.
78.4
26.6
N.A.
N.A.
N.A.
32.8
20.4
N.A.
32.2
29.3
N.A.
N.A.
Protein Similarity:
100
96.6
97.4
92.9
N.A.
84.2
37.9
N.A.
N.A.
N.A.
46.6
34
N.A.
46.4
45.7
N.A.
N.A.
P-Site Identity:
100
100
86.6
86.6
N.A.
73.3
6.6
N.A.
N.A.
N.A.
0
0
N.A.
6.6
0
N.A.
N.A.
P-Site Similarity:
100
100
86.6
86.6
N.A.
73.3
13.3
N.A.
N.A.
N.A.
6.6
13.3
N.A.
33.3
0
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
0
46
0
0
0
0
28
0
10
0
0
10
% A
% Cys:
0
0
0
0
0
10
0
10
0
0
10
0
10
10
0
% C
% Asp:
0
0
19
10
0
0
10
0
0
0
0
0
0
0
10
% D
% Glu:
0
10
55
0
0
10
0
0
0
0
0
10
10
10
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% F
% Gly:
0
0
0
10
0
0
19
0
0
10
0
10
0
0
0
% G
% His:
0
0
0
0
0
0
0
10
0
0
46
0
0
0
0
% H
% Ile:
0
0
0
0
0
10
0
10
28
0
0
0
0
10
0
% I
% Lys:
0
10
0
0
10
10
0
19
0
0
0
0
10
0
0
% K
% Leu:
0
10
0
19
10
10
10
10
0
10
19
19
55
10
19
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
19
0
0
10
10
10
10
0
10
10
0
0
0
0
0
% N
% Pro:
0
0
0
46
10
0
46
0
46
10
0
0
0
46
0
% P
% Gln:
19
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
10
0
0
0
0
10
0
10
0
0
0
0
55
% R
% Ser:
0
19
0
0
0
37
0
0
0
10
19
37
0
10
10
% S
% Thr:
37
10
0
10
10
0
0
37
10
10
0
10
10
10
0
% T
% Val:
19
37
10
0
0
10
0
0
10
10
0
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
10
0
0
0
0
0
10
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _