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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SPHK2
All Species:
18.48
Human Site:
S377
Identified Species:
40.67
UniProt:
Q9NRA0
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NRA0
NP_064511.2
654
69217
S377
H
T
Y
R
G
R
L
S
Y
L
P
A
T
V
E
Chimpanzee
Pan troglodytes
XP_001171276
652
69465
S377
H
T
Y
R
G
R
L
S
Y
L
P
A
T
V
E
Rhesus Macaque
Macaca mulatta
XP_001113908
653
69532
S376
H
T
Y
R
G
R
L
S
Y
L
P
A
T
V
E
Dog
Lupus familis
XP_541516
663
70246
S382
H
T
Y
R
G
R
L
S
Y
L
P
A
A
V
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9JIA7
617
65600
S342
H
T
Y
R
G
R
L
S
Y
L
P
A
T
T
E
Rat
Rattus norvegicus
Q91V26
383
42400
H126
S
L
N
Y
Y
A
G
H
E
Q
V
T
N
E
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001088560
509
55981
Y252
L
A
A
S
I
S
Y
Y
S
G
H
K
Q
A
V
Zebra Danio
Brachydanio rerio
Q7ZW00
422
47526
Q165
G
S
S
N
S
L
S
Q
S
L
H
L
V
S
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_647762
661
73852
L395
Q
R
F
T
V
W
T
L
Y
R
L
V
N
L
R
Honey Bee
Apis mellifera
XP_394823
620
69588
T359
A
R
L
I
G
L
R
T
Y
K
G
K
V
S
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LRB0
763
83573
E438
P
K
Y
S
Y
E
V
E
Y
L
P
A
Q
K
E
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96
96.6
90.8
N.A.
78.4
26.6
N.A.
N.A.
N.A.
32.8
20.4
N.A.
32.2
29.3
N.A.
N.A.
Protein Similarity:
100
96.6
97.4
92.9
N.A.
84.2
37.9
N.A.
N.A.
N.A.
46.6
34
N.A.
46.4
45.7
N.A.
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
93.3
0
N.A.
N.A.
N.A.
0
6.6
N.A.
6.6
13.3
N.A.
N.A.
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
6.6
N.A.
N.A.
N.A.
0
20
N.A.
20
20
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
21.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
37.7
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
10
0
0
10
0
0
0
0
0
55
10
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
19
% D
% Glu:
0
0
0
0
0
10
0
10
10
0
0
0
0
10
55
% E
% Phe:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
10
0
0
0
55
0
10
0
0
10
10
0
0
0
0
% G
% His:
46
0
0
0
0
0
0
10
0
0
19
0
0
0
0
% H
% Ile:
0
0
0
10
10
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
10
0
0
0
0
0
0
0
10
0
19
0
10
0
% K
% Leu:
10
10
10
0
0
19
46
10
0
64
10
10
0
10
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
10
10
0
0
0
0
0
0
0
0
19
0
0
% N
% Pro:
10
0
0
0
0
0
0
0
0
0
55
0
0
0
0
% P
% Gln:
10
0
0
0
0
0
0
10
0
10
0
0
19
0
0
% Q
% Arg:
0
19
0
46
0
46
10
0
0
10
0
0
0
0
10
% R
% Ser:
10
10
10
19
10
10
10
46
19
0
0
0
0
19
0
% S
% Thr:
0
46
0
10
0
0
10
10
0
0
0
10
37
10
0
% T
% Val:
0
0
0
0
10
0
10
0
0
0
10
10
19
37
10
% V
% Trp:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
55
10
19
0
10
10
73
0
0
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _