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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B3
All Species:
38.48
Human Site:
T197
Identified Species:
65.13
UniProt:
Q9NR50
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR50
NP_065098.1
452
50240
T197
H
P
R
I
R
F
H
T
G
L
V
D
A
H
L
Chimpanzee
Pan troglodytes
XP_001152272
452
50208
T197
H
P
R
I
R
F
H
T
G
L
V
D
A
H
L
Rhesus Macaque
Macaca mulatta
XP_001094199
426
47513
T197
Y
P
R
I
R
F
H
T
D
L
V
D
A
H
L
Dog
Lupus familis
XP_532603
452
50384
T197
H
P
R
I
H
F
H
T
G
L
V
D
A
H
L
Cat
Felis silvestris
Mouse
Mus musculus
NP_780344
445
49783
T197
H
P
R
I
H
F
H
T
G
L
V
D
A
H
L
Rat
Rattus norvegicus
P70541
452
50417
T197
H
P
R
I
H
F
Q
T
G
L
V
D
A
H
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508011
644
70516
T195
H
P
R
I
H
F
R
T
G
L
M
D
A
H
L
Chicken
Gallus gallus
NP_001026451
438
48916
T195
H
P
R
M
H
I
R
T
G
L
M
D
A
H
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957368
453
50479
T201
H
P
R
M
F
I
K
T
G
L
L
D
A
H
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611046
455
50653
S200
R
G
R
L
D
V
Y
S
R
L
V
D
A
H
V
Honey Bee
Apis mellifera
XP_395441
457
51785
S204
H
P
S
F
T
M
H
S
K
L
M
D
S
H
L
Nematode Worm
Caenorhab. elegans
P80361
404
44760
D160
S
K
K
P
K
A
T
D
V
M
A
I
V
E
S
Sea Urchin
Strong. purpuratus
XP_797372
388
43828
K157
P
G
T
R
T
K
K
K
S
D
Q
R
D
I
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P09032
578
65681
L259
Y
L
Q
I
R
S
H
L
L
W
N
Y
P
N
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
92.9
89.5
N.A.
83.6
90.4
N.A.
53.1
68.1
N.A.
64.4
N.A.
35.5
35.8
28.9
37.8
Protein Similarity:
100
100
93.8
94.4
N.A.
89.1
95.3
N.A.
63
79.1
N.A.
81
N.A.
57.5
60.1
49.5
56.8
P-Site Identity:
100
100
86.6
93.3
N.A.
93.3
86.6
N.A.
80
66.6
N.A.
66.6
N.A.
40
46.6
0
0
P-Site Similarity:
100
100
93.3
93.3
N.A.
93.3
86.6
N.A.
86.6
80
N.A.
80
N.A.
66.6
66.6
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
8
0
0
0
0
8
0
72
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
8
0
0
8
8
8
0
79
8
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% E
% Phe:
0
0
0
8
8
50
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
15
0
0
0
0
0
0
58
0
0
0
0
0
0
% G
% His:
65
0
0
0
36
0
50
0
0
0
0
0
0
79
0
% H
% Ile:
0
0
0
58
0
15
0
0
0
0
0
8
0
8
8
% I
% Lys:
0
8
8
0
8
8
15
8
8
0
0
0
0
0
0
% K
% Leu:
0
8
0
8
0
0
0
8
8
79
8
0
0
0
79
% L
% Met:
0
0
0
15
0
8
0
0
0
8
22
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
0
% N
% Pro:
8
72
0
8
0
0
0
0
0
0
0
0
8
0
0
% P
% Gln:
0
0
8
0
0
0
8
0
0
0
8
0
0
0
0
% Q
% Arg:
8
0
72
8
29
0
15
0
8
0
0
8
0
0
0
% R
% Ser:
8
0
8
0
0
8
0
15
8
0
0
0
8
0
8
% S
% Thr:
0
0
8
0
15
0
8
65
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
8
0
0
8
0
50
0
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
15
0
0
0
0
0
8
0
0
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _