KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B3
All Species:
20
Human Site:
S294
Identified Species:
33.85
UniProt:
Q9NR50
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR50
NP_065098.1
452
50240
S294
G
D
R
W
E
D
L
S
R
S
Q
V
R
C
Y
Chimpanzee
Pan troglodytes
XP_001152272
452
50208
S294
G
D
R
W
E
D
L
S
R
S
Q
V
R
C
Y
Rhesus Macaque
Macaca mulatta
XP_001094199
426
47513
E291
A
C
R
G
D
R
W
E
D
L
P
R
S
Q
V
Dog
Lupus familis
XP_532603
452
50384
S294
G
E
R
W
E
D
L
S
K
S
Q
V
R
C
Y
Cat
Felis silvestris
Mouse
Mus musculus
NP_780344
445
49783
S294
G
D
K
W
E
D
L
S
R
S
Q
V
R
C
Y
Rat
Rattus norvegicus
P70541
452
50417
S294
R
D
K
W
E
D
L
S
R
S
Q
V
R
C
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508011
644
70516
H292
G
D
V
S
E
D
F
H
G
G
R
V
R
C
Y
Chicken
Gallus gallus
NP_001026451
438
48916
E295
D
M
N
E
T
L
H
E
G
E
K
G
R
C
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957368
453
50479
M295
W
N
D
H
R
G
D
M
S
E
A
Y
H
G
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611046
455
50653
H294
S
L
S
Q
S
P
Y
H
G
D
I
V
R
C
Y
Honey Bee
Apis mellifera
XP_395441
457
51785
H299
T
D
L
E
D
A
Y
H
G
D
I
I
R
C
Y
Nematode Worm
Caenorhab. elegans
P80361
404
44760
T261
P
H
E
N
G
F
V
T
A
H
A
N
T
L
G
Sea Urchin
Strong. purpuratus
XP_797372
388
43828
S250
K
K
Q
F
S
R
I
S
H
A
S
K
A
D
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P09032
578
65681
K376
R
R
S
W
Q
H
S
K
P
R
E
P
I
G
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
92.9
89.5
N.A.
83.6
90.4
N.A.
53.1
68.1
N.A.
64.4
N.A.
35.5
35.8
28.9
37.8
Protein Similarity:
100
100
93.8
94.4
N.A.
89.1
95.3
N.A.
63
79.1
N.A.
81
N.A.
57.5
60.1
49.5
56.8
P-Site Identity:
100
100
6.6
86.6
N.A.
93.3
86.6
N.A.
53.3
13.3
N.A.
0
N.A.
26.6
26.6
0
6.6
P-Site Similarity:
100
100
13.3
100
N.A.
100
93.3
N.A.
60
20
N.A.
6.6
N.A.
26.6
40
13.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
8
0
0
8
8
15
0
8
0
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
65
0
% C
% Asp:
8
43
8
0
15
43
8
0
8
15
0
0
0
8
8
% D
% Glu:
0
8
8
15
43
0
0
15
0
15
8
0
0
0
0
% E
% Phe:
0
0
0
8
0
8
8
0
0
0
0
0
0
0
0
% F
% Gly:
36
0
0
8
8
8
0
0
29
8
0
8
0
15
15
% G
% His:
0
8
0
8
0
8
8
22
8
8
0
0
8
0
0
% H
% Ile:
0
0
0
0
0
0
8
0
0
0
15
8
8
0
8
% I
% Lys:
8
8
15
0
0
0
0
8
8
0
8
8
0
0
0
% K
% Leu:
0
8
8
0
0
8
36
0
0
8
0
0
0
8
0
% L
% Met:
0
8
0
0
0
0
0
8
0
0
0
0
0
0
0
% M
% Asn:
0
8
8
8
0
0
0
0
0
0
0
8
0
0
0
% N
% Pro:
8
0
0
0
0
8
0
0
8
0
8
8
0
0
0
% P
% Gln:
0
0
8
8
8
0
0
0
0
0
36
0
0
8
0
% Q
% Arg:
15
8
29
0
8
15
0
0
29
8
8
8
65
0
0
% R
% Ser:
8
0
15
8
15
0
8
43
8
36
8
0
8
0
0
% S
% Thr:
8
0
0
0
8
0
0
8
0
0
0
0
8
0
0
% T
% Val:
0
0
8
0
0
0
8
0
0
0
0
50
0
0
15
% V
% Trp:
8
0
0
43
0
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
15
0
0
0
0
8
0
0
58
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _