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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B3
All Species:
28.48
Human Site:
S260
Identified Species:
48.21
UniProt:
Q9NR50
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR50
NP_065098.1
452
50240
S260
L
K
K
K
E
L
K
S
L
D
I
Y
S
F
I
Chimpanzee
Pan troglodytes
XP_001152272
452
50208
S260
L
K
K
K
E
L
K
S
L
D
I
Y
S
F
I
Rhesus Macaque
Macaca mulatta
XP_001094199
426
47513
L258
E
D
L
K
K
K
E
L
K
S
L
D
I
Y
S
Dog
Lupus familis
XP_532603
452
50384
S260
L
K
K
K
E
L
K
S
L
D
I
F
S
F
I
Cat
Felis silvestris
Mouse
Mus musculus
NP_780344
445
49783
S260
L
K
K
K
E
L
K
S
L
D
I
Y
S
F
I
Rat
Rattus norvegicus
P70541
452
50417
S260
L
K
K
K
E
P
K
S
L
D
I
Y
S
F
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508011
644
70516
S258
P
K
R
K
D
Q
K
S
L
D
I
Y
S
F
I
Chicken
Gallus gallus
NP_001026451
438
48916
S259
R
K
K
K
E
Q
A
S
L
D
I
Y
S
F
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957368
453
50479
Q261
S
E
K
N
Q
K
Q
Q
E
A
H
I
N
M
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611046
455
50653
K260
S
E
V
G
V
V
T
K
N
E
D
H
V
L
H
Honey Bee
Apis mellifera
XP_395441
457
51785
K265
S
I
V
R
M
N
L
K
E
D
V
Y
R
F
A
Nematode Worm
Caenorhab. elegans
P80361
404
44760
S221
V
L
L
N
L
S
K
S
K
H
I
S
S
F
K
Sea Urchin
Strong. purpuratus
XP_797372
388
43828
V217
M
Y
F
L
K
K
W
V
V
D
F
L
A
D
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P09032
578
65681
T336
D
D
Y
K
P
S
A
T
S
I
Q
P
T
Y
F
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
92.9
89.5
N.A.
83.6
90.4
N.A.
53.1
68.1
N.A.
64.4
N.A.
35.5
35.8
28.9
37.8
Protein Similarity:
100
100
93.8
94.4
N.A.
89.1
95.3
N.A.
63
79.1
N.A.
81
N.A.
57.5
60.1
49.5
56.8
P-Site Identity:
100
100
6.6
93.3
N.A.
100
93.3
N.A.
73.3
80
N.A.
6.6
N.A.
0
20
33.3
6.6
P-Site Similarity:
100
100
33.3
100
N.A.
100
93.3
N.A.
86.6
80
N.A.
33.3
N.A.
26.6
33.3
40
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
15
0
0
8
0
0
8
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
15
0
0
8
0
0
0
0
65
8
8
0
8
8
% D
% Glu:
8
15
0
0
43
0
8
0
15
8
0
0
0
0
0
% E
% Phe:
0
0
8
0
0
0
0
0
0
0
8
8
0
65
8
% F
% Gly:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
8
8
8
0
0
8
% H
% Ile:
0
8
0
0
0
0
0
0
0
8
58
8
8
0
50
% I
% Lys:
0
50
50
65
15
22
50
15
15
0
0
0
0
0
8
% K
% Leu:
36
8
15
8
8
29
8
8
50
0
8
8
0
8
0
% L
% Met:
8
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% M
% Asn:
0
0
0
15
0
8
0
0
8
0
0
0
8
0
0
% N
% Pro:
8
0
0
0
8
8
0
0
0
0
0
8
0
0
0
% P
% Gln:
0
0
0
0
8
15
8
8
0
0
8
0
0
0
0
% Q
% Arg:
8
0
8
8
0
0
0
0
0
0
0
0
8
0
0
% R
% Ser:
22
0
0
0
0
15
0
58
8
8
0
8
58
0
15
% S
% Thr:
0
0
0
0
0
0
8
8
0
0
0
0
8
0
0
% T
% Val:
8
0
15
0
8
8
0
8
8
0
8
0
8
0
0
% V
% Trp:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% W
% Tyr:
0
8
8
0
0
0
0
0
0
0
0
50
0
15
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _