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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B3
All Species:
28.79
Human Site:
S242
Identified Species:
48.72
UniProt:
Q9NR50
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR50
NP_065098.1
452
50240
S242
K
Q
F
S
S
A
S
S
Q
Q
G
Q
E
E
K
Chimpanzee
Pan troglodytes
XP_001152272
452
50208
S242
K
Q
F
S
S
A
S
S
Q
Q
G
Q
E
E
K
Rhesus Macaque
Macaca mulatta
XP_001094199
426
47513
S242
K
Q
F
S
S
A
S
S
Q
Q
G
Q
E
E
K
Dog
Lupus familis
XP_532603
452
50384
S242
K
Q
F
S
S
A
S
S
Q
Q
G
Q
D
E
K
Cat
Felis silvestris
Mouse
Mus musculus
NP_780344
445
49783
S242
K
Q
F
S
S
A
S
S
Q
Q
R
Q
E
D
K
Rat
Rattus norvegicus
P70541
452
50417
S242
K
Q
F
S
S
A
S
S
Q
Q
R
Q
E
D
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508011
644
70516
T240
K
Q
F
S
A
A
A
T
P
R
G
R
D
D
R
Chicken
Gallus gallus
NP_001026451
438
48916
S240
K
Q
F
S
S
P
T
S
L
L
Q
G
L
D
N
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957368
453
50479
N246
K
Q
F
S
K
S
L
N
S
Q
H
V
T
E
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611046
455
50653
P245
K
Q
H
S
K
R
P
P
K
T
V
Q
D
T
T
Honey Bee
Apis mellifera
XP_395441
457
51785
K249
K
Q
F
S
K
P
P
K
Q
C
L
D
D
K
N
Nematode Worm
Caenorhab. elegans
P80361
404
44760
C205
L
T
S
K
Y
N
D
C
H
V
Y
A
I
R
H
Sea Urchin
Strong. purpuratus
XP_797372
388
43828
E202
K
F
P
C
I
Q
F
E
T
R
L
L
D
A
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P09032
578
65681
P304
R
Q
A
S
F
K
D
P
F
T
G
N
Q
Q
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
92.9
89.5
N.A.
83.6
90.4
N.A.
53.1
68.1
N.A.
64.4
N.A.
35.5
35.8
28.9
37.8
Protein Similarity:
100
100
93.8
94.4
N.A.
89.1
95.3
N.A.
63
79.1
N.A.
81
N.A.
57.5
60.1
49.5
56.8
P-Site Identity:
100
100
100
93.3
N.A.
86.6
86.6
N.A.
40
40
N.A.
40
N.A.
26.6
33.3
0
6.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
93.3
N.A.
93.3
53.3
N.A.
53.3
N.A.
40
46.6
0
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
8
50
8
0
0
0
0
8
0
8
0
% A
% Cys:
0
0
0
8
0
0
0
8
0
8
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
15
0
0
0
0
8
36
29
8
% D
% Glu:
0
0
0
0
0
0
0
8
0
0
0
0
36
36
0
% E
% Phe:
0
8
72
0
8
0
8
0
8
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
43
8
0
0
0
% G
% His:
0
0
8
0
0
0
0
0
8
0
8
0
0
0
15
% H
% Ile:
0
0
0
0
8
0
0
0
0
0
0
0
8
0
0
% I
% Lys:
86
0
0
8
22
8
0
8
8
0
0
0
0
8
43
% K
% Leu:
8
0
0
0
0
0
8
0
8
8
15
8
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
8
0
0
0
8
0
0
15
% N
% Pro:
0
0
8
0
0
15
15
15
8
0
0
0
0
0
0
% P
% Gln:
0
86
0
0
0
8
0
0
50
50
8
50
8
8
8
% Q
% Arg:
8
0
0
0
0
8
0
0
0
15
15
8
0
8
8
% R
% Ser:
0
0
8
86
50
8
43
50
8
0
0
0
0
0
0
% S
% Thr:
0
8
0
0
0
0
8
8
8
15
0
0
8
8
8
% T
% Val:
0
0
0
0
0
0
0
0
0
8
8
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
8
0
0
0
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _