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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2B3
All Species:
37.88
Human Site:
S185
Identified Species:
64.1
UniProt:
Q9NR50
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NR50
NP_065098.1
452
50240
S185
E
E
L
V
I
K
G
S
I
L
Q
K
H
P
R
Chimpanzee
Pan troglodytes
XP_001152272
452
50208
S185
E
E
L
V
I
K
G
S
I
L
Q
K
H
P
R
Rhesus Macaque
Macaca mulatta
XP_001094199
426
47513
S185
E
E
L
V
I
K
G
S
I
L
Q
K
Y
P
R
Dog
Lupus familis
XP_532603
452
50384
S185
E
E
L
V
I
K
G
S
I
L
Q
K
H
P
R
Cat
Felis silvestris
Mouse
Mus musculus
NP_780344
445
49783
S185
E
E
L
V
I
K
G
S
I
L
Q
K
H
P
R
Rat
Rattus norvegicus
P70541
452
50417
S185
E
E
L
V
I
K
G
S
I
L
Q
K
H
P
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508011
644
70516
S183
E
E
L
V
I
K
R
S
I
L
H
K
H
P
R
Chicken
Gallus gallus
NP_001026451
438
48916
S183
E
E
L
V
I
K
R
S
I
L
Q
K
H
P
R
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_957368
453
50479
S189
E
G
L
V
L
R
K
S
I
M
R
K
H
P
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_611046
455
50653
H188
E
T
L
N
I
Q
R
H
L
L
K
N
R
G
R
Honey Bee
Apis mellifera
XP_395441
457
51785
T192
E
T
I
K
I
T
Q
T
L
L
K
K
H
P
S
Nematode Worm
Caenorhab. elegans
P80361
404
44760
A148
D
T
C
V
N
A
P
A
P
G
S
K
S
K
K
Sea Urchin
Strong. purpuratus
XP_797372
388
43828
E145
Q
Q
A
D
Q
G
L
E
G
M
T
V
P
G
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P09032
578
65681
V247
D
V
Y
S
Q
R
D
V
T
K
T
K
Y
L
Q
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
92.9
89.5
N.A.
83.6
90.4
N.A.
53.1
68.1
N.A.
64.4
N.A.
35.5
35.8
28.9
37.8
Protein Similarity:
100
100
93.8
94.4
N.A.
89.1
95.3
N.A.
63
79.1
N.A.
81
N.A.
57.5
60.1
49.5
56.8
P-Site Identity:
100
100
93.3
100
N.A.
100
100
N.A.
86.6
93.3
N.A.
60
N.A.
33.3
40
13.3
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
86.6
93.3
N.A.
86.6
N.A.
53.3
66.6
33.3
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
40.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
0
8
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% D
% Glu:
79
58
0
0
0
0
0
8
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
8
43
0
8
8
0
0
0
15
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
8
0
65
0
0
% H
% Ile:
0
0
8
0
72
0
0
0
65
0
0
0
0
0
0
% I
% Lys:
0
0
0
8
0
58
8
0
0
8
15
86
0
8
8
% K
% Leu:
0
0
72
0
8
0
8
0
15
72
0
0
0
8
0
% L
% Met:
0
0
0
0
0
0
0
0
0
15
0
0
0
0
0
% M
% Asn:
0
0
0
8
8
0
0
0
0
0
0
8
0
0
0
% N
% Pro:
0
0
0
0
0
0
8
0
8
0
0
0
8
72
0
% P
% Gln:
8
8
0
0
15
8
8
0
0
0
50
0
0
0
8
% Q
% Arg:
0
0
0
0
0
15
22
0
0
0
8
0
8
0
72
% R
% Ser:
0
0
0
8
0
0
0
65
0
0
8
0
8
0
8
% S
% Thr:
0
22
0
0
0
8
0
8
8
0
15
0
0
0
8
% T
% Val:
0
8
0
72
0
0
0
8
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
8
0
0
0
0
0
0
0
0
0
15
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _