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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ITM2C
All Species:
37.27
Human Site:
T227
Identified Species:
91.11
UniProt:
Q9NQX7
Number Species:
9
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NQX7
NP_001012532.1
267
30224
T227
H
L
C
N
G
K
D
T
Y
R
L
R
R
R
A
Chimpanzee
Pan troglodytes
XP_516140
349
39546
T309
H
L
C
N
G
K
D
T
Y
R
L
R
R
Q
A
Rhesus Macaque
Macaca mulatta
XP_001112946
267
30191
T227
H
L
C
N
G
K
D
T
Y
R
L
R
R
R
A
Dog
Lupus familis
XP_543282
267
30078
T227
H
L
C
S
G
K
D
T
Y
R
L
R
R
R
A
Cat
Felis silvestris
Mouse
Mus musculus
Q91VK4
269
30464
T229
H
L
C
N
G
K
D
T
Y
R
L
R
R
R
S
Rat
Rattus norvegicus
Q5PQL7
269
30462
T229
H
L
C
N
G
K
D
T
Y
R
L
R
R
R
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001513545
268
30897
T228
R
M
C
H
G
K
E
T
Y
K
L
Q
R
R
E
Chicken
Gallus gallus
O42204
262
29991
T223
R
L
C
R
G
K
E
T
Y
K
L
Q
R
K
E
Frog
Xenopus laevis
NP_001080382
257
29963
T218
R
L
C
R
D
K
D
T
Y
K
L
Q
R
K
E
Zebra Danio
Brachydanio rerio
NP_956274
260
30517
T218
R
L
C
Y
A
K
E
T
Y
R
L
R
R
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
69.9
99.6
93.6
N.A.
92.9
92.9
N.A.
42.5
45.6
44.1
56.5
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
74.2
100
96.6
N.A.
96.6
97
N.A.
63.4
65.1
61.7
72.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
93.3
100
93.3
N.A.
93.3
100
N.A.
53.3
53.3
53.3
66.6
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
86.6
80
73.3
80
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
50
% A
% Cys:
0
0
100
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
0
70
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
30
0
0
0
0
0
0
0
30
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
80
0
0
0
0
0
0
0
0
0
0
% G
% His:
60
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
100
0
0
0
30
0
0
0
20
0
% K
% Leu:
0
90
0
0
0
0
0
0
0
0
100
0
0
0
0
% L
% Met:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
50
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
30
0
10
0
% Q
% Arg:
40
0
0
20
0
0
0
0
0
70
0
70
100
70
0
% R
% Ser:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
20
% S
% Thr:
0
0
0
0
0
0
0
100
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
10
0
0
0
0
100
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _