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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TCF7L1 All Species: 18.79
Human Site: Y395 Identified Species: 51.67
UniProt: Q9HCS4 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCS4 NP_112573.1 588 62631 Y395 S R E E Q A K Y Y E L A R K E
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001083116 589 62673 Y396 S R E E Q A K Y Y E L A R K E
Dog Lupus familis XP_854889 710 75046 Y517 S R E E Q A K Y Y E L A R K E
Cat Felis silvestris
Mouse Mus musculus Q9Z1J1 584 62280 Y391 S R E E Q A K Y Y E L A R K E
Rat Rattus norvegicus Q9QXN1 397 44005 T206 P G G V G Q I T P P L G W Q G
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_421760 598 65290 Y376 S R E E Q A K Y Y E L A R K E
Frog Xenopus laevis P70062 554 60282 W362 N Q I L G R R W H S L S R E E
Zebra Danio Brachydanio rerio Q9YHE8 560 61441 W367 N Q I L G R R W H S L S R E E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q10666 438 48576 M246 E Q A K Y F E M A K K D K E T
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98.8 80.9 N.A. 95.2 40.4 N.A. N.A. 61.3 75.1 71.7 N.A. N.A. N.A. 22.7 N.A.
Protein Similarity: 100 N.A. 99.1 81.4 N.A. 96.2 49.4 N.A. N.A. 72.7 83.1 79.7 N.A. N.A. N.A. 38.7 N.A.
P-Site Identity: 100 N.A. 100 100 N.A. 100 6.6 N.A. N.A. 100 20 20 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 100 N.A. 100 100 N.A. 100 13.3 N.A. N.A. 100 66.6 66.6 N.A. N.A. N.A. 40 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 12 0 0 56 0 0 12 0 0 56 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % D
% Glu: 12 0 56 56 0 0 12 0 0 56 0 0 0 34 78 % E
% Phe: 0 0 0 0 0 12 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 12 12 0 34 0 0 0 0 0 0 12 0 0 12 % G
% His: 0 0 0 0 0 0 0 0 23 0 0 0 0 0 0 % H
% Ile: 0 0 23 0 0 0 12 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 12 0 0 56 0 0 12 12 0 12 56 0 % K
% Leu: 0 0 0 23 0 0 0 0 0 0 89 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 12 0 0 0 0 0 0 0 % M
% Asn: 23 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 12 0 0 0 0 0 0 0 12 12 0 0 0 0 0 % P
% Gln: 0 34 0 0 56 12 0 0 0 0 0 0 0 12 0 % Q
% Arg: 0 56 0 0 0 23 23 0 0 0 0 0 78 0 0 % R
% Ser: 56 0 0 0 0 0 0 0 0 23 0 23 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 12 0 0 0 0 0 0 12 % T
% Val: 0 0 0 12 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 23 0 0 0 0 12 0 0 % W
% Tyr: 0 0 0 0 12 0 0 56 56 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _