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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TCF7L1
All Species:
12.42
Human Site:
S325
Identified Species:
34.17
UniProt:
Q9HCS4
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9HCS4
NP_112573.1
588
62631
S325
E
P
A
P
P
S
L
S
P
A
V
S
V
K
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001083116
589
62673
S326
E
P
A
P
P
S
L
S
P
A
V
S
A
K
S
Dog
Lupus familis
XP_854889
710
75046
S447
E
P
A
P
P
S
L
S
P
A
V
S
A
K
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9Z1J1
584
62280
S321
E
P
A
A
P
S
L
S
P
A
V
S
A
K
S
Rat
Rattus norvegicus
Q9QXN1
397
44005
V142
R
T
S
N
K
V
P
V
V
Q
P
S
H
A
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_421760
598
65290
G306
E
S
S
Q
S
D
V
G
S
L
H
S
S
K
H
Frog
Xenopus laevis
P70062
554
60282
P297
S
P
I
V
K
Q
E
P
S
S
G
N
I
S
P
Zebra Danio
Brachydanio rerio
Q9YHE8
560
61441
K299
A
I
V
S
P
A
I
K
Q
E
P
N
G
E
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10666
438
48576
G182
N
V
D
R
R
A
Q
G
G
G
K
A
K
K
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.8
80.9
N.A.
95.2
40.4
N.A.
N.A.
61.3
75.1
71.7
N.A.
N.A.
N.A.
22.7
N.A.
Protein Similarity:
100
N.A.
99.1
81.4
N.A.
96.2
49.4
N.A.
N.A.
72.7
83.1
79.7
N.A.
N.A.
N.A.
38.7
N.A.
P-Site Identity:
100
N.A.
93.3
93.3
N.A.
86.6
6.6
N.A.
N.A.
20
6.6
13.3
N.A.
N.A.
N.A.
6.6
N.A.
P-Site Similarity:
100
N.A.
93.3
93.3
N.A.
86.6
13.3
N.A.
N.A.
33.3
26.6
40
N.A.
N.A.
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
12
0
45
12
0
23
0
0
0
45
0
12
34
12
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
12
0
0
12
0
0
0
0
0
0
0
0
12
% D
% Glu:
56
0
0
0
0
0
12
0
0
12
0
0
0
12
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
23
12
12
12
0
12
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
12
0
12
0
12
% H
% Ile:
0
12
12
0
0
0
12
0
0
0
0
0
12
0
0
% I
% Lys:
0
0
0
0
23
0
0
12
0
0
12
0
12
67
0
% K
% Leu:
0
0
0
0
0
0
45
0
0
12
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
12
0
0
12
0
0
0
0
0
0
0
23
0
0
0
% N
% Pro:
0
56
0
34
56
0
12
12
45
0
23
0
0
0
12
% P
% Gln:
0
0
0
12
0
12
12
0
12
12
0
0
0
0
0
% Q
% Arg:
12
0
0
12
12
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
12
12
23
12
12
45
0
45
23
12
0
67
12
12
56
% S
% Thr:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
12
12
12
0
12
12
12
12
0
45
0
12
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _