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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TCF7L1 All Species: 4.24
Human Site: S22 Identified Species: 11.67
UniProt: Q9HCS4 Number Species: 8
    Phosphosite Substitution
    Charge Score: 0.38
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9HCS4 NP_112573.1 588 62631 S22 S G G G G G S S A G A A G G G
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001083116 589 62673 S23 S G G G S G S S A G A A G G G
Dog Lupus familis XP_854889 710 75046 G144 G G G G G G S G A G A A G G G
Cat Felis silvestris
Mouse Mus musculus Q9Z1J1 584 62280 G19 G G G G G G S G A G A T S G G
Rat Rattus norvegicus Q9QXN1 397 44005
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_421760 598 65290 D11 L N G G G G D D L G A N D E L
Frog Xenopus laevis P70062 554 60282 E11 L N S G G G D E L G A N D E L
Zebra Danio Brachydanio rerio Q9YHE8 560 61441 D11 L N G G G G D D L G A N D E L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q10666 438 48576
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98.8 80.9 N.A. 95.2 40.4 N.A. N.A. 61.3 75.1 71.7 N.A. N.A. N.A. 22.7 N.A.
Protein Similarity: 100 N.A. 99.1 81.4 N.A. 96.2 49.4 N.A. N.A. 72.7 83.1 79.7 N.A. N.A. N.A. 38.7 N.A.
P-Site Identity: 100 N.A. 93.3 86.6 N.A. 73.3 0 N.A. N.A. 40 33.3 40 N.A. N.A. N.A. 0 N.A.
P-Site Similarity: 100 N.A. 93.3 86.6 N.A. 73.3 0 N.A. N.A. 40 33.3 40 N.A. N.A. N.A. 0 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 45 0 78 34 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 34 23 0 0 0 0 34 0 0 % D
% Glu: 0 0 0 0 0 0 0 12 0 0 0 0 0 34 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 23 45 67 78 67 78 0 23 0 78 0 0 34 45 45 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % K
% Leu: 34 0 0 0 0 0 0 0 34 0 0 0 0 0 34 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 34 0 0 0 0 0 0 0 0 0 34 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 23 0 12 0 12 0 45 23 0 0 0 0 12 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 12 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _