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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2C4
All Species:
22.73
Human Site:
Y435
Identified Species:
41.67
UniProt:
Q9HCK5
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9HCK5
NP_060099.2
861
97097
Y435
D
M
R
G
K
Q
F
Y
A
G
I
E
I
K
V
Chimpanzee
Pan troglodytes
XP_524663
1051
117595
Y625
D
M
R
G
K
Q
F
Y
A
G
I
E
I
K
V
Rhesus Macaque
Macaca mulatta
XP_001100725
1053
117937
H637
D
M
R
N
K
Q
F
H
T
G
I
E
I
K
V
Dog
Lupus familis
XP_539597
877
99324
Y451
D
M
R
G
K
Q
F
Y
A
G
I
E
I
K
V
Cat
Felis silvestris
Mouse
Mus musculus
Q8CJF8
861
97018
Y435
D
M
R
G
K
Q
F
Y
A
G
I
E
I
K
V
Rat
Rattus norvegicus
Q9QZ81
860
97300
H444
D
M
R
N
K
Q
F
H
T
G
I
E
I
K
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510187
878
98879
Y452
D
M
R
G
K
Q
F
Y
A
G
I
E
I
K
V
Chicken
Gallus gallus
Q5ZMW0
794
89512
L399
L
K
S
F
T
D
Q
L
R
K
I
S
K
D
A
Frog
Xenopus laevis
Q4KLV6
884
99519
Y458
D
M
R
G
K
Q
F
Y
A
G
I
E
I
K
V
Zebra Danio
Brachydanio rerio
A3KPK0
860
97313
H444
D
M
R
G
K
Q
F
H
T
G
V
E
I
K
M
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUQ5
1214
136831
R765
N
L
D
P
T
I
S
R
F
G
I
R
I
A
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34681
1040
115397
Q581
G
S
W
T
M
D
N
Q
T
L
Y
M
P
A
T
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04379
1048
116172
N598
M
M
N
K
K
M
I
N
G
G
T
V
N
N
W
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.9
63.2
97.4
N.A.
98.8
78.4
N.A.
97.3
91.7
94.9
81.4
N.A.
20.1
N.A.
31.9
N.A.
Protein Similarity:
100
81.9
72.1
97.6
N.A.
99.7
88.6
N.A.
97.6
92
96.6
89.7
N.A.
33.7
N.A.
49.7
N.A.
P-Site Identity:
100
100
80
100
N.A.
100
80
N.A.
100
6.6
100
73.3
N.A.
20
N.A.
0
N.A.
P-Site Similarity:
100
100
86.6
100
N.A.
100
86.6
N.A.
100
6.6
100
93.3
N.A.
33.3
N.A.
0
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
47
0
0
0
0
16
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
70
0
8
0
0
16
0
0
0
0
0
0
0
8
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
70
0
0
0
% E
% Phe:
0
0
0
8
0
0
70
0
8
0
0
0
0
0
0
% F
% Gly:
8
0
0
54
0
0
0
0
8
85
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
24
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
8
8
0
0
0
77
0
77
0
0
% I
% Lys:
0
8
0
8
77
0
0
0
0
8
0
0
8
70
0
% K
% Leu:
8
8
0
0
0
0
0
8
0
8
0
0
0
0
0
% L
% Met:
8
77
0
0
8
8
0
0
0
0
0
8
0
0
8
% M
% Asn:
8
0
8
16
0
0
8
8
0
0
0
0
8
8
8
% N
% Pro:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% P
% Gln:
0
0
0
0
0
70
8
8
0
0
0
0
0
0
0
% Q
% Arg:
0
0
70
0
0
0
0
8
8
0
0
8
0
0
0
% R
% Ser:
0
8
8
0
0
0
8
0
0
0
0
8
0
0
0
% S
% Thr:
0
0
0
8
16
0
0
0
31
0
8
0
0
0
8
% T
% Val:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
62
% V
% Trp:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
0
47
0
0
8
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _