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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2C4
All Species:
30
Human Site:
T418
Identified Species:
55
UniProt:
Q9HCK5
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9HCK5
NP_060099.2
861
97097
T418
Q
Y
G
G
R
N
K
T
V
A
T
P
N
Q
G
Chimpanzee
Pan troglodytes
XP_524663
1051
117595
T608
Q
Y
G
G
R
N
K
T
V
A
T
P
N
Q
G
Rhesus Macaque
Macaca mulatta
XP_001100725
1053
117937
A620
L
Y
G
G
R
N
K
A
I
A
T
P
V
Q
G
Dog
Lupus familis
XP_539597
877
99324
T434
Q
Y
G
G
R
N
K
T
V
A
T
P
N
Q
G
Cat
Felis silvestris
Mouse
Mus musculus
Q8CJF8
861
97018
T418
Q
Y
G
G
R
N
K
T
V
A
T
P
S
Q
G
Rat
Rattus norvegicus
Q9QZ81
860
97300
A427
L
Y
G
G
R
N
K
A
I
A
T
P
V
Q
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510187
878
98879
T435
Q
Y
G
G
R
N
K
T
V
A
T
P
N
Q
G
Chicken
Gallus gallus
Q5ZMW0
794
89512
A382
V
W
A
V
A
C
F
A
P
Q
K
Q
C
R
E
Frog
Xenopus laevis
Q4KLV6
884
99519
T441
Q
Y
G
G
R
N
K
T
V
A
T
P
N
Q
G
Zebra Danio
Brachydanio rerio
A3KPK0
860
97313
T427
Q
Y
G
G
R
N
R
T
V
A
T
P
S
H
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUQ5
1214
136831
I748
T
N
V
R
K
R
K
I
M
N
L
L
Q
Y
F
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34681
1040
115397
S564
M
F
G
G
N
N
R
S
V
N
P
V
V
F
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04379
1048
116172
T581
H
E
S
G
R
E
G
T
C
L
P
Q
V
G
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.9
63.2
97.4
N.A.
98.8
78.4
N.A.
97.3
91.7
94.9
81.4
N.A.
20.1
N.A.
31.9
N.A.
Protein Similarity:
100
81.9
72.1
97.6
N.A.
99.7
88.6
N.A.
97.6
92
96.6
89.7
N.A.
33.7
N.A.
49.7
N.A.
P-Site Identity:
100
100
73.3
100
N.A.
93.3
73.3
N.A.
100
0
100
80
N.A.
6.6
N.A.
26.6
N.A.
P-Site Similarity:
100
100
80
100
N.A.
100
80
N.A.
100
13.3
100
93.3
N.A.
20
N.A.
46.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
0
8
0
0
24
0
70
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
8
0
0
8
0
0
0
8
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
8
0
0
0
8
0
0
0
0
0
0
0
0
8
% E
% Phe:
0
8
0
0
0
0
8
0
0
0
0
0
0
8
8
% F
% Gly:
0
0
77
85
0
0
8
0
0
0
0
0
0
8
70
% G
% His:
8
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% H
% Ile:
0
0
0
0
0
0
0
8
16
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
8
0
70
0
0
0
8
0
0
0
0
% K
% Leu:
16
0
0
0
0
0
0
0
0
8
8
8
0
0
0
% L
% Met:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% M
% Asn:
0
8
0
0
8
77
0
0
0
16
0
0
39
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
8
0
16
70
0
0
8
% P
% Gln:
54
0
0
0
0
0
0
0
0
8
0
16
8
62
8
% Q
% Arg:
0
0
0
8
77
8
16
0
0
0
0
0
0
8
0
% R
% Ser:
0
0
8
0
0
0
0
8
0
0
0
0
16
0
0
% S
% Thr:
8
0
0
0
0
0
0
62
0
0
70
0
0
0
0
% T
% Val:
8
0
8
8
0
0
0
0
62
0
0
8
31
0
0
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
70
0
0
0
0
0
0
0
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _