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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2C4
All Species:
37.88
Human Site:
T241
Identified Species:
69.44
UniProt:
Q9HCK5
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9HCK5
NP_060099.2
861
97097
T241
N
E
Q
T
K
P
L
T
D
S
Q
R
V
K
F
Chimpanzee
Pan troglodytes
XP_524663
1051
117595
T431
N
E
Q
T
K
P
L
T
D
S
Q
R
V
K
F
Rhesus Macaque
Macaca mulatta
XP_001100725
1053
117937
T443
E
E
Q
Q
K
P
L
T
D
S
Q
R
V
K
F
Dog
Lupus familis
XP_539597
877
99324
T257
N
E
Q
T
K
P
L
T
D
S
Q
R
V
K
F
Cat
Felis silvestris
Mouse
Mus musculus
Q8CJF8
861
97018
T241
N
E
Q
T
K
P
L
T
D
S
Q
R
V
K
F
Rat
Rattus norvegicus
Q9QZ81
860
97300
T252
E
E
Q
Q
K
P
L
T
D
S
Q
R
V
K
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510187
878
98879
T258
N
E
Q
T
K
P
L
T
D
S
Q
R
V
K
F
Chicken
Gallus gallus
Q5ZMW0
794
89512
R209
Y
R
V
C
N
V
T
R
R
P
A
S
H
Q
T
Frog
Xenopus laevis
Q4KLV6
884
99519
T264
N
E
Q
T
K
P
L
T
D
S
Q
R
V
K
F
Zebra Danio
Brachydanio rerio
A3KPK0
860
97313
T252
D
E
Q
P
R
P
L
T
D
S
H
R
V
K
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUQ5
1214
136831
N563
F
K
M
S
D
P
N
N
R
H
E
L
D
D
G
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34681
1040
115397
Q389
D
T
L
S
R
D
T
Q
L
S
S
F
E
T
R
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04379
1048
116172
S407
D
I
S
S
R
P
L
S
D
A
D
R
V
K
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.9
63.2
97.4
N.A.
98.8
78.4
N.A.
97.3
91.7
94.9
81.4
N.A.
20.1
N.A.
31.9
N.A.
Protein Similarity:
100
81.9
72.1
97.6
N.A.
99.7
88.6
N.A.
97.6
92
96.6
89.7
N.A.
33.7
N.A.
49.7
N.A.
P-Site Identity:
100
100
86.6
100
N.A.
100
86.6
N.A.
100
0
100
73.3
N.A.
6.6
N.A.
6.6
N.A.
P-Site Similarity:
100
100
86.6
100
N.A.
100
86.6
N.A.
100
6.6
100
86.6
N.A.
26.6
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
8
8
0
0
0
0
% A
% Cys:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
24
0
0
0
8
8
0
0
77
0
8
0
8
8
0
% D
% Glu:
16
70
0
0
0
0
0
0
0
0
8
0
8
0
0
% E
% Phe:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
70
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
8
8
0
8
0
0
% H
% Ile:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
8
% I
% Lys:
0
8
0
0
62
0
0
0
0
0
0
0
0
77
0
% K
% Leu:
0
0
8
0
0
0
77
0
8
0
0
8
0
0
0
% L
% Met:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
47
0
0
0
8
0
8
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
8
0
85
0
0
0
8
0
0
0
0
0
% P
% Gln:
0
0
70
16
0
0
0
8
0
0
62
0
0
8
0
% Q
% Arg:
0
8
0
0
24
0
0
8
16
0
0
77
0
0
8
% R
% Ser:
0
0
8
24
0
0
0
8
0
77
8
8
0
0
0
% S
% Thr:
0
8
0
47
0
0
16
70
0
0
0
0
0
8
8
% T
% Val:
0
0
8
0
0
8
0
0
0
0
0
0
77
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _