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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF2C4
All Species:
22.73
Human Site:
S577
Identified Species:
41.67
UniProt:
Q9HCK5
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9HCK5
NP_060099.2
861
97097
S577
L
V
P
H
Q
R
P
S
V
F
Q
Q
P
V
I
Chimpanzee
Pan troglodytes
XP_524663
1051
117595
S767
L
V
P
H
Q
R
P
S
V
F
Q
Q
P
V
I
Rhesus Macaque
Macaca mulatta
XP_001100725
1053
117937
P774
G
V
N
N
I
L
L
P
Q
G
R
P
P
V
F
Dog
Lupus familis
XP_539597
877
99324
S593
L
V
P
H
Q
R
P
S
V
F
Q
Q
P
V
I
Cat
Felis silvestris
Mouse
Mus musculus
Q8CJF8
861
97018
S577
L
V
P
H
Q
R
P
S
V
F
Q
Q
P
V
I
Rat
Rattus norvegicus
Q9QZ81
860
97300
P581
G
V
N
N
I
L
L
P
Q
G
R
P
P
V
F
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510187
878
98879
S594
L
V
P
H
Q
R
P
S
V
F
Q
Q
P
V
I
Chicken
Gallus gallus
Q5ZMW0
794
89512
G520
Q
Q
P
V
I
F
L
G
A
D
V
T
H
P
P
Frog
Xenopus laevis
Q4KLV6
884
99519
S600
L
V
P
H
Q
R
P
S
V
F
Q
Q
P
V
I
Zebra Danio
Brachydanio rerio
A3KPK0
860
97313
P581
G
I
N
N
I
L
V
P
H
Q
R
P
S
V
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUQ5
1214
136831
C924
Q
F
T
V
E
R
K
C
N
N
Q
T
I
G
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
P34681
1040
115397
V723
G
G
I
N
S
R
I
V
A
D
K
I
T
N
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04379
1048
116172
L748
A
L
S
R
R
I
P
L
V
S
D
R
P
T
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
81.9
63.2
97.4
N.A.
98.8
78.4
N.A.
97.3
91.7
94.9
81.4
N.A.
20.1
N.A.
31.9
N.A.
Protein Similarity:
100
81.9
72.1
97.6
N.A.
99.7
88.6
N.A.
97.6
92
96.6
89.7
N.A.
33.7
N.A.
49.7
N.A.
P-Site Identity:
100
100
20
100
N.A.
100
20
N.A.
100
6.6
100
6.6
N.A.
13.3
N.A.
6.6
N.A.
P-Site Similarity:
100
100
33.3
100
N.A.
100
33.3
N.A.
100
6.6
100
26.6
N.A.
20
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
36.9
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
0
0
0
0
16
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
16
8
0
0
0
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
8
0
0
0
8
0
0
0
47
0
0
0
0
24
% F
% Gly:
31
8
0
0
0
0
0
8
0
16
0
0
0
8
0
% G
% His:
0
0
0
47
0
0
0
0
8
0
0
0
8
0
0
% H
% Ile:
0
8
8
0
31
8
8
0
0
0
0
8
8
0
54
% I
% Lys:
0
0
0
0
0
0
8
0
0
0
8
0
0
0
8
% K
% Leu:
47
8
0
0
0
24
24
8
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
24
31
0
0
0
0
8
8
0
0
0
8
8
% N
% Pro:
0
0
54
0
0
0
54
24
0
0
0
24
70
8
8
% P
% Gln:
16
8
0
0
47
0
0
0
16
8
54
47
0
0
0
% Q
% Arg:
0
0
0
8
8
62
0
0
0
0
24
8
0
0
0
% R
% Ser:
0
0
8
0
8
0
0
47
0
8
0
0
8
0
0
% S
% Thr:
0
0
8
0
0
0
0
0
0
0
0
16
8
8
0
% T
% Val:
0
62
0
16
0
0
8
8
54
0
8
0
0
70
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _