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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMBIM4
All Species:
4.55
Human Site:
Y94
Identified Species:
7.69
UniProt:
Q9HC24
Number Species:
13
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9HC24
NP_057140.2
238
26959
Y94
L
T
L
N
R
H
K
Y
P
L
N
L
Y
L
L
Chimpanzee
Pan troglodytes
XP_001162738
238
26906
Y94
L
T
L
N
R
H
K
Y
P
L
N
L
Y
L
L
Rhesus Macaque
Macaca mulatta
XP_001117063
225
25339
L94
L
L
F
G
F
T
L
L
E
A
L
T
V
A
V
Dog
Lupus familis
XP_531662
238
26812
H94
L
T
V
N
R
H
K
H
P
L
N
L
Y
L
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9DA39
238
26628
H94
L
T
L
H
R
H
T
H
P
L
N
L
Y
L
L
Rat
Rattus norvegicus
O88407
316
35017
F165
C
S
G
P
R
R
H
F
P
W
N
L
I
L
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510640
238
26687
H94
L
T
F
Y
R
H
K
H
P
T
N
L
Y
L
L
Chicken
Gallus gallus
XP_001235093
237
26659
V95
L
Y
R
H
Q
H
P
V
N
L
Y
L
L
F
G
Frog
Xenopus laevis
NP_001089282
235
26315
N94
Y
R
Q
Q
Y
P
V
N
L
Y
L
L
L
A
F
Zebra Danio
Brachydanio rerio
NP_998303
236
26689
V94
F
Y
R
H
Q
H
P
V
N
L
Y
L
L
F
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11080
276
30391
V133
L
H
V
Y
A
R
E
V
P
L
N
Y
V
L
L
Sea Urchin
Strong. purpuratus
XP_001177352
238
26595
P94
M
V
K
S
K
E
Y
P
I
N
M
I
L
L
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94A20
256
28150
H109
L
H
I
Y
H
Q
K
H
P
V
N
L
I
L
L
Baker's Yeast
Sacchar. cerevisiae
P48558
297
33627
E110
L
A
V
S
P
R
P
E
D
Y
E
A
S
V
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
91.5
89
N.A.
84.4
23.1
N.A.
81.9
77.3
70.5
64.7
N.A.
N.A.
N.A.
30.7
50.4
Protein Similarity:
100
99.5
92.8
95.3
N.A.
93.2
38.2
N.A.
89.9
85.7
86.1
84
N.A.
N.A.
N.A.
51.8
73.1
P-Site Identity:
100
100
6.6
86.6
N.A.
80
40
N.A.
73.3
26.6
6.6
20
N.A.
N.A.
N.A.
40
6.6
P-Site Similarity:
100
100
13.3
100
N.A.
93.3
53.3
N.A.
80
40
6.6
33.3
N.A.
N.A.
N.A.
53.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.1
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.5
44.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
46.6
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
66.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
8
0
0
0
0
8
0
8
0
15
0
% A
% Cys:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
8
8
8
8
0
8
0
0
0
0
% E
% Phe:
8
0
15
0
8
0
0
8
0
0
0
0
0
15
8
% F
% Gly:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
15
% G
% His:
0
15
0
22
8
50
8
29
0
0
0
0
0
0
0
% H
% Ile:
0
0
8
0
0
0
0
0
8
0
0
8
15
0
0
% I
% Lys:
0
0
8
0
8
0
36
0
0
0
0
0
0
0
0
% K
% Leu:
72
8
22
0
0
0
8
8
8
50
15
72
29
65
58
% L
% Met:
8
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% M
% Asn:
0
0
0
22
0
0
0
8
15
8
58
0
0
0
0
% N
% Pro:
0
0
0
8
8
8
22
8
58
0
0
0
0
0
8
% P
% Gln:
0
0
8
8
15
8
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
8
15
0
43
22
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
8
0
15
0
0
0
0
0
0
0
0
8
0
0
% S
% Thr:
0
36
0
0
0
8
8
0
0
8
0
8
0
0
8
% T
% Val:
0
8
22
0
0
0
8
22
0
8
0
0
15
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
8
0
0
0
0
0
% W
% Tyr:
8
15
0
22
8
0
8
15
0
15
15
8
36
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _