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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMBIM4
All Species:
31.82
Human Site:
Y19
Identified Species:
53.85
UniProt:
Q9HC24
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9HC24
NP_057140.2
238
26959
Y19
S
I
E
D
D
F
N
Y
G
S
S
V
A
S
A
Chimpanzee
Pan troglodytes
XP_001162738
238
26906
Y19
S
I
E
D
D
F
N
Y
G
S
S
V
A
S
A
Rhesus Macaque
Macaca mulatta
XP_001117063
225
25339
Y19
S
I
E
D
D
F
N
Y
G
S
S
V
A
S
A
Dog
Lupus familis
XP_531662
238
26812
Y19
S
I
E
E
D
F
N
Y
G
S
C
V
A
S
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9DA39
238
26628
Y19
S
I
E
D
D
F
N
Y
G
S
C
V
A
S
A
Rat
Rattus norvegicus
O88407
316
35017
T90
G
H
H
E
L
F
S
T
F
S
W
D
D
Q
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510640
238
26687
Y19
S
I
E
D
D
F
N
Y
G
S
S
V
A
S
A
Chicken
Gallus gallus
XP_001235093
237
26659
S20
E
D
D
F
N
Y
G
S
N
V
A
S
A
S
V
Frog
Xenopus laevis
NP_001089282
235
26315
N19
D
D
F
N
Y
G
T
N
V
A
S
A
S
I
Q
Zebra Danio
Brachydanio rerio
NP_998303
236
26689
T19
E
D
D
F
N
Y
G
T
N
V
A
T
A
S
V
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11080
276
30391
L58
I
V
D
A
D
G
I
L
P
G
C
V
G
K
A
Sea Urchin
Strong. purpuratus
XP_001177352
238
26595
S19
V
L
D
D
F
H
H
S
T
S
V
M
S
A
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94A20
256
28150
L34
M
G
V
G
E
A
T
L
Y
P
G
L
S
Y
G
Baker's Yeast
Sacchar. cerevisiae
P48558
297
33627
Y35
F
I
P
E
D
F
K
Y
S
T
V
V
I
S
C
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
91.5
89
N.A.
84.4
23.1
N.A.
81.9
77.3
70.5
64.7
N.A.
N.A.
N.A.
30.7
50.4
Protein Similarity:
100
99.5
92.8
95.3
N.A.
93.2
38.2
N.A.
89.9
85.7
86.1
84
N.A.
N.A.
N.A.
51.8
73.1
P-Site Identity:
100
100
100
86.6
N.A.
93.3
13.3
N.A.
100
13.3
6.6
13.3
N.A.
N.A.
N.A.
20
13.3
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
26.6
N.A.
100
40
26.6
40
N.A.
N.A.
N.A.
33.3
53.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.1
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.5
44.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
40
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
8
0
0
0
8
15
8
58
8
50
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
22
0
0
0
8
% C
% Asp:
8
22
29
43
58
0
0
0
0
0
0
8
8
0
0
% D
% Glu:
15
0
43
22
8
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
8
0
8
15
8
58
0
0
8
0
0
0
0
0
0
% F
% Gly:
8
8
0
8
0
15
15
0
43
8
8
0
8
0
8
% G
% His:
0
8
8
0
0
8
8
0
0
0
0
0
0
0
8
% H
% Ile:
8
50
0
0
0
0
8
0
0
0
0
0
8
8
0
% I
% Lys:
0
0
0
0
0
0
8
0
0
0
0
0
0
8
8
% K
% Leu:
0
8
0
0
8
0
0
15
0
0
0
8
0
0
0
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% M
% Asn:
0
0
0
8
15
0
43
8
15
0
0
0
0
0
0
% N
% Pro:
0
0
8
0
0
0
0
0
8
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
8
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
43
0
0
0
0
0
8
15
8
58
36
8
22
65
0
% S
% Thr:
0
0
0
0
0
0
15
15
8
8
0
8
0
0
0
% T
% Val:
8
8
8
0
0
0
0
0
8
15
15
58
0
0
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
0
8
15
0
50
8
0
0
0
0
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _