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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TMBIM4
All Species:
17.58
Human Site:
S216
Identified Species:
29.74
UniProt:
Q9HC24
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9HC24
NP_057140.2
238
26959
S216
E
Y
V
L
A
A
I
S
L
Y
L
D
I
I
N
Chimpanzee
Pan troglodytes
XP_001162738
238
26906
S216
E
Y
V
L
A
A
I
S
L
Y
L
D
I
I
N
Rhesus Macaque
Macaca mulatta
XP_001117063
225
25339
N210
S
L
Y
L
D
I
I
N
L
F
L
H
L
L
R
Dog
Lupus familis
XP_531662
238
26812
S216
E
Y
V
L
A
A
I
S
L
Y
L
D
V
I
N
Cat
Felis silvestris
Mouse
Mus musculus
Q9DA39
238
26628
S216
E
Y
V
I
A
A
I
S
L
Y
M
D
I
I
N
Rat
Rattus norvegicus
O88407
316
35017
N295
E
Y
I
F
G
A
L
N
I
Y
L
D
I
I
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510640
238
26687
N216
E
Y
I
L
A
S
I
N
L
Y
L
D
I
I
N
Chicken
Gallus gallus
XP_001235093
237
26659
N215
E
Y
I
L
A
A
I
N
L
Y
L
D
I
I
N
Frog
Xenopus laevis
NP_001089282
235
26315
N213
E
Y
I
L
A
S
V
N
L
Y
L
D
I
I
N
Zebra Danio
Brachydanio rerio
NP_998303
236
26689
N214
E
H
V
L
A
S
I
N
L
Y
L
D
I
V
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q11080
276
30391
S255
D
Y
I
C
A
C
V
S
L
Y
M
D
I
L
N
Sea Urchin
Strong. purpuratus
XP_001177352
238
26595
N216
E
Y
I
M
A
S
I
N
L
Y
L
D
L
I
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q94A20
256
28150
A235
E
Y
I
L
A
S
V
A
L
Y
L
D
I
L
N
Baker's Yeast
Sacchar. cerevisiae
P48558
297
33627
M274
E
E
V
R
C
A
M
M
L
Y
L
D
I
V
N
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.7
91.5
89
N.A.
84.4
23.1
N.A.
81.9
77.3
70.5
64.7
N.A.
N.A.
N.A.
30.7
50.4
Protein Similarity:
100
99.5
92.8
95.3
N.A.
93.2
38.2
N.A.
89.9
85.7
86.1
84
N.A.
N.A.
N.A.
51.8
73.1
P-Site Identity:
100
100
26.6
93.3
N.A.
86.6
53.3
N.A.
80
86.6
73.3
73.3
N.A.
N.A.
N.A.
53.3
66.6
P-Site Similarity:
100
100
53.3
100
N.A.
100
80
N.A.
100
100
100
100
N.A.
N.A.
N.A.
86.6
100
Percent
Protein Identity:
N.A.
N.A.
N.A.
37.1
28.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
53.5
44.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
66.6
60
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
100
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
79
50
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
8
8
8
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
0
0
8
0
0
0
0
0
0
93
0
0
0
% D
% Glu:
86
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
8
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
50
8
0
8
65
0
8
0
0
0
79
65
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
8
0
65
0
0
8
0
93
0
86
0
15
22
0
% L
% Met:
0
0
0
8
0
0
8
8
0
0
15
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
50
0
0
0
0
0
0
86
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
8
% R
% Ser:
8
0
0
0
0
36
0
36
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
43
0
0
0
22
0
0
0
0
0
8
15
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
79
8
0
0
0
0
0
0
93
0
0
0
0
8
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _