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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLR1B All Species: 30.91
Human Site: Y840 Identified Species: 48.57
UniProt: Q9H9Y6 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H9Y6 NP_001131076.1 1135 128229 Y840 T G E S F V M Y Y K S K E N C
Chimpanzee Pan troglodytes XP_515692 1135 128294 Y840 T G E S F V M Y Y K S K E N C
Rhesus Macaque Macaca mulatta XP_001088474 1135 128257 Y840 T G E S F V M Y Y K S K E N C
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P70700 1135 127957 Y840 T G E G F V V Y Y K S K E N C
Rat Rattus norvegicus O54888 1135 127691 Y840 T G E G F V V Y Y K S K E N C
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515678 1146 129549 Y851 T G E S F V T Y Y K S K E D C
Chicken Gallus gallus XP_415007 1041 117633 Y746 T G E T F T V Y Y Q N K E V G
Frog Xenopus laevis NP_001080005 1134 128197 Y839 T G E S F V A Y Y K S K E N C
Zebra Danio Brachydanio rerio NP_956812 1132 127666 F837 T G Q S H V Y F Y K Y Q E S C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P20028 1129 128426 V831 E V A T Y K V V K M D E K E D
Honey Bee Apis mellifera XP_001120416 1121 127333 G826 D Q S T Y I T G K Y H G K E D
Nematode Worm Caenorhab. elegans Q10578 1193 134886 A898 K K Y P K R D A S T F L R S S
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P38420 1188 135001 H898 S R Y T R R D H S I S L R H S
Baker's Yeast Sacchar. cerevisiae P22138 1203 135723 Y874 N K T K I K T Y H S S E P A Y
Red Bread Mold Neurospora crassa O74633 1234 138583 R889 D G V T H Y E R Y K D S E D A
Conservation
Percent
Protein Identity: 100 99.5 98.6 N.A. N.A. 89.6 85.2 N.A. 83.5 68.1 77 75.7 N.A. 45.2 47.1 28.3 N.A.
Protein Similarity: 100 99.8 99.5 N.A. N.A. 95.4 90.3 N.A. 92.8 79.5 88.9 89.2 N.A. 64.9 66 44.9 N.A.
P-Site Identity: 100 100 100 N.A. N.A. 86.6 86.6 N.A. 86.6 53.3 93.3 53.3 N.A. 0 0 0 N.A.
P-Site Similarity: 100 100 100 N.A. N.A. 93.3 93.3 N.A. 93.3 80 93.3 80 N.A. 33.3 26.6 6.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 25.8 42.4 44
Protein Similarity: N.A. N.A. N.A. 42.8 61.9 60.7
P-Site Identity: N.A. N.A. N.A. 6.6 13.3 26.6
P-Site Similarity: N.A. N.A. N.A. 33.3 26.6 40
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 0 0 7 7 0 0 0 0 0 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 54 % C
% Asp: 14 0 0 0 0 0 14 0 0 0 14 0 0 14 14 % D
% Glu: 7 0 54 0 0 0 7 0 0 0 0 14 67 14 0 % E
% Phe: 0 0 0 0 54 0 0 7 0 0 7 0 0 0 0 % F
% Gly: 0 67 0 14 0 0 0 7 0 0 0 7 0 0 7 % G
% His: 0 0 0 0 14 0 0 7 7 0 7 0 0 7 0 % H
% Ile: 0 0 0 0 7 7 0 0 0 7 0 0 0 0 0 % I
% Lys: 7 14 0 7 7 14 0 0 14 60 0 54 14 0 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 14 0 0 0 % L
% Met: 0 0 0 0 0 0 20 0 0 7 0 0 0 0 0 % M
% Asn: 7 0 0 0 0 0 0 0 0 0 7 0 0 40 0 % N
% Pro: 0 0 0 7 0 0 0 0 0 0 0 0 7 0 0 % P
% Gln: 0 7 7 0 0 0 0 0 0 7 0 7 0 0 0 % Q
% Arg: 0 7 0 0 7 14 0 7 0 0 0 0 14 0 0 % R
% Ser: 7 0 7 40 0 0 0 0 14 7 60 7 0 14 14 % S
% Thr: 60 0 7 34 0 7 20 0 0 7 0 0 0 0 0 % T
% Val: 0 7 7 0 0 54 27 7 0 0 0 0 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 14 0 14 7 7 60 67 7 7 0 0 0 7 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _