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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: POLR1B All Species: 51.82
Human Site: S981 Identified Species: 81.43
UniProt: Q9H9Y6 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H9Y6 NP_001131076.1 1135 128229 S981 Y G T E R L Y S G I S G L E L
Chimpanzee Pan troglodytes XP_515692 1135 128294 S981 Y G T E R L Y S G I S G L E L
Rhesus Macaque Macaca mulatta XP_001088474 1135 128257 S981 Y G T E R L Y S G I S G L E L
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus P70700 1135 127957 S981 Y G T E R L Y S G I S G M E L
Rat Rattus norvegicus O54888 1135 127691 S981 Y G T E R L Y S G I S G M E L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001515678 1146 129549 S992 Y G T E K L Y S G I S G L E L
Chicken Gallus gallus XP_415007 1041 117633 S887 F G T E K M Y S G I S G V E L
Frog Xenopus laevis NP_001080005 1134 128197 S980 Y G T E K L Y S G I S G L E L
Zebra Danio Brachydanio rerio NP_956812 1132 127666 S978 Y G T E R L Y S G L S G L E L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P20028 1129 128426 S972 Y G T E R L Y S G V D G R E M
Honey Bee Apis mellifera XP_001120416 1121 127333 S967 Y G T E R M Y S G I D G R E M
Nematode Worm Caenorhab. elegans Q10578 1193 134886 T1039 E V M Y N G H T G K K L T T Q
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P38420 1188 135001 G1039 R M Y N G H T G R P L T A M I
Baker's Yeast Sacchar. cerevisiae P22138 1203 135723 S1015 H G N E P M Y S G A T G E E L
Red Bread Mold Neurospora crassa O74633 1234 138583 S1030 H G N E P L Y S G I T G E E F
Conservation
Percent
Protein Identity: 100 99.5 98.6 N.A. N.A. 89.6 85.2 N.A. 83.5 68.1 77 75.7 N.A. 45.2 47.1 28.3 N.A.
Protein Similarity: 100 99.8 99.5 N.A. N.A. 95.4 90.3 N.A. 92.8 79.5 88.9 89.2 N.A. 64.9 66 44.9 N.A.
P-Site Identity: 100 100 100 N.A. N.A. 93.3 93.3 N.A. 93.3 73.3 93.3 93.3 N.A. 73.3 73.3 6.6 N.A.
P-Site Similarity: 100 100 100 N.A. N.A. 100 100 N.A. 100 100 100 100 N.A. 86.6 86.6 20 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 25.8 42.4 44
Protein Similarity: N.A. N.A. N.A. 42.8 61.9 60.7
P-Site Identity: N.A. N.A. N.A. 0 53.3 60
P-Site Similarity: N.A. N.A. N.A. 6.6 73.3 73.3
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 7 0 0 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 14 0 0 0 0 % D
% Glu: 7 0 0 87 0 0 0 0 0 0 0 0 14 87 0 % E
% Phe: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % F
% Gly: 0 87 0 0 7 7 0 7 94 0 0 87 0 0 0 % G
% His: 14 0 0 0 0 7 7 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 67 0 0 0 0 7 % I
% Lys: 0 0 0 0 20 0 0 0 0 7 7 0 0 0 0 % K
% Leu: 0 0 0 0 0 67 0 0 0 7 7 7 40 0 67 % L
% Met: 0 7 7 0 0 20 0 0 0 0 0 0 14 7 14 % M
% Asn: 0 0 14 7 7 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 0 0 0 0 14 0 0 0 0 7 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % Q
% Arg: 7 0 0 0 54 0 0 0 7 0 0 0 14 0 0 % R
% Ser: 0 0 0 0 0 0 0 87 0 0 60 0 0 0 0 % S
% Thr: 0 0 74 0 0 0 7 7 0 0 14 7 7 7 0 % T
% Val: 0 7 0 0 0 0 0 0 0 7 0 0 7 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 67 0 7 7 0 0 87 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _