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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SH2D4A
All Species:
29.09
Human Site:
S384
Identified Species:
91.43
UniProt:
Q9H788
Number Species:
7
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H788
NP_071354.2
454
52727
S384
R
I
K
G
Y
A
L
S
Y
L
S
E
D
G
C
Chimpanzee
Pan troglodytes
XP_001148190
454
52742
S384
R
I
K
G
Y
A
L
S
Y
L
S
E
D
G
C
Rhesus Macaque
Macaca mulatta
XP_001099045
454
52578
S384
R
I
K
G
Y
A
L
S
H
L
S
E
D
S
C
Dog
Lupus familis
XP_848220
453
51924
S383
R
I
K
G
Y
A
L
S
Y
L
S
A
E
G
C
Cat
Felis silvestris
Mouse
Mus musculus
Q9D7V1
421
48442
S351
K
I
K
G
Y
A
L
S
Y
L
S
E
E
G
C
Rat
Rattus norvegicus
Q6AYC8
422
48504
S352
K
I
K
G
Y
A
L
S
Y
L
S
E
E
G
C
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507878
464
53528
S394
K
M
K
G
Y
V
L
S
Y
L
S
R
E
G
C
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_781629
470
56428
S391
R
I
W
G
Y
A
L
S
F
R
D
K
E
R
A
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.8
94.7
84.3
N.A.
73.7
73.5
N.A.
67
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
35.7
Protein Similarity:
100
98.6
97.3
90.5
N.A.
81
81
N.A.
79.7
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
55.7
P-Site Identity:
100
100
86.6
86.6
N.A.
86.6
86.6
N.A.
66.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
46.6
P-Site Similarity:
100
100
93.3
93.3
N.A.
100
100
N.A.
86.6
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
66.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
88
0
0
0
0
0
13
0
0
13
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
88
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
13
0
38
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
0
63
63
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% F
% Gly:
0
0
0
100
0
0
0
0
0
0
0
0
0
75
0
% G
% His:
0
0
0
0
0
0
0
0
13
0
0
0
0
0
0
% H
% Ile:
0
88
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
38
0
88
0
0
0
0
0
0
0
0
13
0
0
0
% K
% Leu:
0
0
0
0
0
0
100
0
0
88
0
0
0
0
0
% L
% Met:
0
13
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
63
0
0
0
0
0
0
0
0
13
0
13
0
13
0
% R
% Ser:
0
0
0
0
0
0
0
100
0
0
88
0
0
13
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
13
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
13
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
100
0
0
0
75
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _