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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NARFL All Species: 33.03
Human Site: S451 Identified Species: 55.9
UniProt: Q9H6Q4 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9H6Q4 NP_071938.1 476 53020 S451 H W L Q G T D S E C A G R L L
Chimpanzee Pan troglodytes XP_510719 476 53016 S451 H W L Q G T D S E C A G R L L
Rhesus Macaque Macaca mulatta XP_001118535 427 47271 S402 H W L Q G T D S E C A G R L L
Dog Lupus familis XP_547207 476 52934 S451 S W L Q G E G S E Q A G R L L
Cat Felis silvestris
Mouse Mus musculus Q7TMW6 476 53090 S451 H W L Q G E D S E R A S R L L
Rat Rattus norvegicus Q5BK18 476 53149 S451 H W L Q G E D S E R A S H L L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513248 469 52242 S444 D W L Q G T D S P K V Q A A L
Chicken Gallus gallus XP_414836 476 53145 S451 Q W L G G P E S E K A R K A L
Frog Xenopus laevis Q6GP25 456 51492 S431 D W L Q G A E S Q K T K Q T L
Zebra Danio Brachydanio rerio A2RRV9 411 46081 E386 S W L E S V G E E K A R Q L L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q8SYS7 477 54516 S451 D F L D G F Q S D K S Y D V L
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q9N392 457 50805 L432 V R E E W E K L D K N Y R N L
Sea Urchin Strong. purpuratus XP_001191432 475 53102 S450 E W L G G V G S E K A R T M L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa Q7SGW5 581 62269 S556 T S Y R E V V S D V G K E K K
Conservation
Percent
Protein Identity: 100 99.5 83.8 86.1 N.A. 87.6 86.1 N.A. 47.9 71.8 44.7 57.1 N.A. 48.6 N.A. 35.9 63.2
Protein Similarity: 100 100 85.9 93.9 N.A. 93.9 93 N.A. 65.3 85.5 64.2 70.1 N.A. 67.7 N.A. 55.6 79.6
P-Site Identity: 100 100 100 73.3 N.A. 80 73.3 N.A. 53.3 46.6 40 40 N.A. 26.6 N.A. 13.3 46.6
P-Site Similarity: 100 100 100 73.3 N.A. 80 73.3 N.A. 53.3 60 60 53.3 N.A. 53.3 N.A. 26.6 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. 32.7
Protein Similarity: N.A. N.A. N.A. N.A. N.A. 47.1
P-Site Identity: N.A. N.A. N.A. N.A. N.A. 6.6
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. 20
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 8 0 0 0 0 65 0 8 15 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 22 0 0 0 0 0 % C
% Asp: 22 0 0 8 0 0 43 0 22 0 0 0 8 0 0 % D
% Glu: 8 0 8 15 8 29 15 8 65 0 0 0 8 0 0 % E
% Phe: 0 8 0 0 0 8 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 15 79 0 22 0 0 0 8 29 0 0 0 % G
% His: 36 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 8 0 0 50 0 15 8 8 8 % K
% Leu: 0 0 86 0 0 0 0 8 0 0 0 0 0 50 93 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 8 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 8 0 0 8 0 % N
% Pro: 0 0 0 0 0 8 0 0 8 0 0 0 0 0 0 % P
% Gln: 8 0 0 58 0 0 8 0 8 8 0 8 15 0 0 % Q
% Arg: 0 8 0 8 0 0 0 0 0 15 0 22 43 0 0 % R
% Ser: 15 8 0 0 8 0 0 86 0 0 8 15 0 0 0 % S
% Thr: 8 0 0 0 0 29 0 0 0 0 8 0 8 8 0 % T
% Val: 8 0 0 0 0 22 8 0 0 8 8 0 0 8 0 % V
% Trp: 0 79 0 0 8 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 8 0 0 0 0 0 0 0 0 15 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _