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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN23
All Species:
9.7
Human Site:
S747
Identified Species:
23.7
UniProt:
Q9H3S7
Number Species:
9
Phosphosite Substitution
Charge Score:
-0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H3S7
NP_056281.1
1636
178974
S747
D
P
P
E
E
L
R
S
L
P
P
D
M
V
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001100428
1769
194164
S884
D
P
P
E
E
L
R
S
L
P
P
D
M
V
A
Dog
Lupus familis
XP_851530
1262
137623
L487
S
E
E
K
A
K
L
L
R
E
M
M
A
K
I
Cat
Felis silvestris
Mouse
Mus musculus
Q6PB44
1692
185198
S750
D
T
P
E
E
L
R
S
L
P
P
D
M
M
V
Rat
Rattus norvegicus
O88902
1499
163435
G642
A
A
V
P
M
A
P
G
P
V
L
Y
P
A
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001345811
2003
220166
S745
D
P
E
L
A
E
L
S
A
A
I
L
A
L
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_648722
1833
200310
V762
N
P
A
Y
V
P
T
V
R
P
V
P
V
G
S
Honey Bee
Apis mellifera
XP_623844
1770
200065
P767
V
Y
K
E
Q
S
K
P
V
Q
I
D
T
T
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796684
1298
141735
K523
K
M
Q
K
L
V
T
K
V
D
E
M
K
T
Q
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SAN9
1012
112176
I237
V
W
L
S
V
V
Q
I
K
L
N
F
M
N
S
Conservation
Percent
Protein Identity:
100
N.A.
90.2
65.2
N.A.
88.7
79.9
N.A.
N.A.
N.A.
N.A.
54.2
N.A.
27.3
26.9
N.A.
32.1
Protein Similarity:
100
N.A.
90.7
67.3
N.A.
91.4
82.6
N.A.
N.A.
N.A.
N.A.
65.1
N.A.
43.4
44.3
N.A.
47.6
P-Site Identity:
100
N.A.
100
0
N.A.
80
0
N.A.
N.A.
N.A.
N.A.
20
N.A.
13.3
13.3
N.A.
0
P-Site Similarity:
100
N.A.
100
6.6
N.A.
86.6
0
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
33.3
33.3
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
20.6
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
34.1
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
10
0
20
10
0
0
10
10
0
0
20
10
20
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
40
0
0
0
0
0
0
0
0
10
0
40
0
0
0
% D
% Glu:
0
10
20
40
30
10
0
0
0
10
10
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
10
0
0
0
0
0
10
10
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
10
0
0
20
0
0
0
10
% I
% Lys:
10
0
10
20
0
10
10
10
10
0
0
0
10
10
10
% K
% Leu:
0
0
10
10
10
30
20
10
30
10
10
10
0
10
0
% L
% Met:
0
10
0
0
10
0
0
0
0
0
10
20
40
10
0
% M
% Asn:
10
0
0
0
0
0
0
0
0
0
10
0
0
10
0
% N
% Pro:
0
40
30
10
0
10
10
10
10
40
30
10
10
0
10
% P
% Gln:
0
0
10
0
10
0
10
0
0
10
0
0
0
0
10
% Q
% Arg:
0
0
0
0
0
0
30
0
20
0
0
0
0
0
0
% R
% Ser:
10
0
0
10
0
10
0
40
0
0
0
0
0
0
20
% S
% Thr:
0
10
0
0
0
0
20
0
0
0
0
0
10
20
0
% T
% Val:
20
0
10
0
20
20
0
10
20
10
10
0
10
20
10
% V
% Trp:
0
10
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
10
0
0
0
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _