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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS11
All Species:
35.76
Human Site:
Y681
Identified Species:
60.51
UniProt:
Q9H270
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9H270
NP_068375.3
941
107837
Y681
D
F
Q
D
G
V
L
Y
L
Y
E
Q
G
K
L
Chimpanzee
Pan troglodytes
XP_508805
941
107763
Y681
D
F
Q
D
G
V
L
Y
L
Y
E
Q
G
K
L
Rhesus Macaque
Macaca mulatta
XP_001101032
941
107684
Y681
D
F
Q
D
G
V
L
Y
L
Y
E
Q
G
K
L
Dog
Lupus familis
XP_546492
941
107605
Y681
D
F
Q
D
G
V
L
Y
L
Y
E
Q
G
K
L
Cat
Felis silvestris
Mouse
Mus musculus
Q91W86
941
107751
Y681
D
F
Q
D
G
V
L
Y
L
Y
E
Q
G
K
L
Rat
Rattus norvegicus
NP_001101608
878
101153
K624
L
Y
L
Y
E
Q
G
K
L
F
Q
Q
I
M
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_417847
929
106402
Y669
N
F
K
D
G
V
L
Y
L
Y
E
Q
G
K
L
Frog
Xenopus laevis
NP_001088406
914
104616
Y654
N
F
Q
N
G
V
L
Y
L
Y
E
Q
G
K
L
Zebra Danio
Brachydanio rerio
XP_002663611
927
106605
Y666
N
F
K
E
G
V
L
Y
L
Y
E
K
G
K
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393972
1079
122741
F672
N
F
K
R
G
L
L
F
L
Y
E
E
N
K
L
Nematode Worm
Caenorhab. elegans
Q09600
980
111990
H660
D
C
T
P
V
I
E
H
I
L
M
R
C
H
K
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002321189
962
108854
Y713
A
F
K
D
G
L
L
Y
L
Y
E
K
M
K
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_027676
932
105695
I684
Y
D
V
D
L
A
V
I
L
C
E
M
N
S
F
Baker's Yeast
Sacchar. cerevisiae
P12868
1029
117459
A777
K
I
D
I
A
S
F
A
N
D
N
P
E
M
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
99.2
98
N.A.
97.9
91.5
N.A.
N.A.
83.5
77.4
74.1
N.A.
N.A.
41.3
26.4
N.A.
Protein Similarity:
100
99.8
99.5
98.9
N.A.
98.9
92.4
N.A.
N.A.
91.5
86.7
85.2
N.A.
N.A.
58.2
46.9
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
13.3
N.A.
N.A.
86.6
86.6
73.3
N.A.
N.A.
53.3
6.6
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
33.3
N.A.
N.A.
100
100
100
N.A.
N.A.
86.6
33.3
N.A.
Percent
Protein Identity:
38.4
N.A.
N.A.
40.8
20.8
N.A.
Protein Similarity:
57.3
N.A.
N.A.
60.8
39.4
N.A.
P-Site Identity:
66.6
N.A.
N.A.
20
0
N.A.
P-Site Similarity:
86.6
N.A.
N.A.
26.6
0
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
0
0
0
8
8
0
8
0
0
0
0
0
0
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
8
0
0
8
0
0
% C
% Asp:
43
8
8
58
0
0
0
0
0
8
0
0
0
0
8
% D
% Glu:
0
0
0
8
8
0
8
0
0
0
79
8
8
0
0
% E
% Phe:
0
72
0
0
0
0
8
8
0
8
0
0
0
0
8
% F
% Gly:
0
0
0
0
72
0
8
0
0
0
0
0
58
0
0
% G
% His:
0
0
0
0
0
0
0
8
0
0
0
0
0
8
8
% H
% Ile:
0
8
0
8
0
8
0
8
8
0
0
0
8
0
0
% I
% Lys:
8
0
29
0
0
0
0
8
0
0
0
15
0
72
8
% K
% Leu:
8
0
8
0
8
15
72
0
86
8
0
0
0
0
72
% L
% Met:
0
0
0
0
0
0
0
0
0
0
8
8
8
15
0
% M
% Asn:
29
0
0
8
0
0
0
0
8
0
8
0
15
0
0
% N
% Pro:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% P
% Gln:
0
0
43
0
0
8
0
0
0
0
8
58
0
0
0
% Q
% Arg:
0
0
0
8
0
0
0
0
0
0
0
8
0
0
0
% R
% Ser:
0
0
0
0
0
8
0
0
0
0
0
0
0
8
0
% S
% Thr:
0
0
8
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
8
0
8
58
8
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
8
0
8
0
0
0
65
0
72
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _