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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC12A9 All Species: 27.58
Human Site: Y259 Identified Species: 55.15
UniProt: Q9BXP2 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BXP2 NP_064631.2 914 96110 Y259 G A G Y A E D Y T T G A V M N
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001105778 914 96183 Y259 A A G Y A E D Y T T G A M M N
Dog Lupus familis XP_546947 916 96148 Y259 G A G Y A K D Y T T G A M M T
Cat Felis silvestris
Mouse Mus musculus Q99MR3 914 96295 Y259 G A G Y A E D Y T T G A M M T
Rat Rattus norvegicus Q66HR0 914 95986 Y259 G A G Y A E D Y T T G A M M T
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus
Frog Xenopus laevis Q0VGW6 899 98326 Y262 Q A D Y S L D Y T T G N L M N
Zebra Danio Brachydanio rerio A2BFP5 899 98457 Y265 G P R Y S L D Y S T N T M M S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_609887 941 104229 T287 S H Y G R D Y T S N G K Q V D
Honey Bee Apis mellifera XP_395129 948 104316 Y287 Y S N Y S R D Y S S E G T M T
Nematode Worm Caenorhab. elegans Q09573 1020 112280 V371 R G K E T A E V V Q D E S S T
Sea Urchin Strong. purpuratus XP_791143 838 92404 G241 P G R A I P L G T L G G C L F
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P38329 1120 123980 S276 L T K G A A G S L L K G K E T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 98.8 93.4 N.A. 93.4 93.8 N.A. N.A. N.A. 61 58.3 N.A. 41.9 42.5 21 41.7
Protein Similarity: 100 N.A. 99 95.7 N.A. 95.7 96.1 N.A. N.A. N.A. 73.9 71.4 N.A. 58.8 58.8 36.8 58.4
P-Site Identity: 100 N.A. 86.6 80 N.A. 86.6 86.6 N.A. N.A. N.A. 60 40 N.A. 6.6 26.6 0 13.3
P-Site Similarity: 100 N.A. 93.3 93.3 N.A. 93.3 93.3 N.A. N.A. N.A. 73.3 66.6 N.A. 33.3 53.3 6.6 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. 28.9 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 47.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 6.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 50 0 9 50 17 0 0 0 0 0 42 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % C
% Asp: 0 0 9 0 0 9 67 0 0 0 9 0 0 0 9 % D
% Glu: 0 0 0 9 0 34 9 0 0 0 9 9 0 9 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 9 % F
% Gly: 42 17 42 17 0 0 9 9 0 0 67 25 0 0 0 % G
% His: 0 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 9 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 17 0 0 9 0 0 0 0 9 9 9 0 0 % K
% Leu: 9 0 0 0 0 17 9 0 9 17 0 0 9 9 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 42 67 0 % M
% Asn: 0 0 9 0 0 0 0 0 0 9 9 9 0 0 25 % N
% Pro: 9 9 0 0 0 9 0 0 0 0 0 0 0 0 0 % P
% Gln: 9 0 0 0 0 0 0 0 0 9 0 0 9 0 0 % Q
% Arg: 9 0 17 0 9 9 0 0 0 0 0 0 0 0 0 % R
% Ser: 9 9 0 0 25 0 0 9 25 9 0 0 9 9 9 % S
% Thr: 0 9 0 0 9 0 0 9 59 59 0 9 9 0 50 % T
% Val: 0 0 0 0 0 0 0 9 9 0 0 0 9 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 9 67 0 0 9 67 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _