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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ALG12 All Species: 8.79
Human Site: Y335 Identified Species: 14.87
UniProt: Q9BV10 Number Species: 13
    Phosphosite Substitution
    Charge Score: -0.23
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q9BV10 NP_077010.1 488 54655 Y335 C S Y L L N N Y K K S W L Y K
Chimpanzee Pan troglodytes XP_001139922 488 54695 Y335 C S Y L L N N Y K K S W L Y K
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_848418 491 54333 Y337 C A C L L N N Y R K S W L Y K
Cat Felis silvestris
Mouse Mus musculus Q8VDB2 483 53807 I323 Y T F P V L N I M A A R G C T
Rat Rattus norvegicus NP_001101574 488 54690 K336 C T Y V L N K K S W P Y K V R
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505566 492 55335 N337 R L R A P L N N Y R K S W L Y
Chicken Gallus gallus XP_001232188 340 38807 W190 L N N Y R K S W L Y K L G S L
Frog Xenopus laevis Q4V7R2 531 61428 R371 F S F S N L K R W K K A A V G
Zebra Danio Brachydanio rerio Q7SXZ1 536 62222 A365 L S L A K L Q A W R K A A A G
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VH78 678 76534 N323 A C Q R I W M N S A K S T W H
Honey Bee Apis mellifera XP_001122829 360 40954 F210 T S P F L W Y F Y S A L P R G
Nematode Worm Caenorhab. elegans Q23361 492 57131 R331 C A R M L I N R H K S F F R M
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana NP_001077448 497 57174 N338 A A S R I Y N N R K K T I W K
Baker's Yeast Sacchar. cerevisiae P53730 551 62654 L351 G A T G A A H L W E N M K V K
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.1 N.A. 80 N.A. 77.2 79.5 N.A. 65.2 47.1 21 21.2 N.A. 36.4 36.2 37.4 N.A.
Protein Similarity: 100 98.7 N.A. 87.5 N.A. 85.4 87.5 N.A. 78.8 56.5 38.6 38 N.A. 49.4 51.2 56.2 N.A.
P-Site Identity: 100 100 N.A. 80 N.A. 6.6 26.6 N.A. 6.6 0 13.3 6.6 N.A. 0 13.3 33.3 N.A.
P-Site Similarity: 100 100 N.A. 93.3 N.A. 33.3 53.3 N.A. 13.3 20 20 13.3 N.A. 13.3 26.6 53.3 N.A.
Percent
Protein Identity: N.A. N.A. N.A. 38 31.4 N.A.
Protein Similarity: N.A. N.A. N.A. 58.3 49.5 N.A.
P-Site Identity: N.A. N.A. N.A. 20 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 53.3 33.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 29 0 15 8 8 0 8 0 15 15 15 15 8 0 % A
% Cys: 36 8 8 0 0 0 0 0 0 0 0 0 0 8 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % E
% Phe: 8 0 15 8 0 0 0 8 0 0 0 8 8 0 0 % F
% Gly: 8 0 0 8 0 0 0 0 0 0 0 0 15 0 22 % G
% His: 0 0 0 0 0 0 8 0 8 0 0 0 0 0 8 % H
% Ile: 0 0 0 0 15 8 0 8 0 0 0 0 8 0 0 % I
% Lys: 0 0 0 0 8 8 15 8 15 43 43 0 15 0 36 % K
% Leu: 15 8 8 22 43 29 0 8 8 0 0 15 22 8 8 % L
% Met: 0 0 0 8 0 0 8 0 8 0 0 8 0 0 8 % M
% Asn: 0 8 8 0 8 29 50 22 0 0 8 0 0 0 0 % N
% Pro: 0 0 8 8 8 0 0 0 0 0 8 0 8 0 0 % P
% Gln: 0 0 8 0 0 0 8 0 0 0 0 0 0 0 0 % Q
% Arg: 8 0 15 15 8 0 0 15 15 15 0 8 0 15 8 % R
% Ser: 0 36 8 8 0 0 8 0 15 8 29 15 0 8 0 % S
% Thr: 8 15 8 0 0 0 0 0 0 0 0 8 8 0 8 % T
% Val: 0 0 0 8 8 0 0 0 0 0 0 0 0 22 0 % V
% Trp: 0 0 0 0 0 15 0 8 22 8 0 22 8 15 0 % W
% Tyr: 8 0 22 8 0 8 8 22 15 8 0 8 0 22 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _