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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PLCD4
All Species:
26.97
Human Site:
S422
Identified Species:
45.64
UniProt:
Q9BRC7
Number Species:
13
Phosphosite Substitution
Charge Score:
0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9BRC7
NP_116115.1
762
87585
S422
V
L
P
T
Q
L
P
S
P
E
E
L
R
R
K
Chimpanzee
Pan troglodytes
XP_526029
762
87514
S422
V
L
P
T
Q
L
P
S
P
E
E
L
R
R
K
Rhesus Macaque
Macaca mulatta
XP_001091488
799
91444
S422
V
L
P
T
Q
L
P
S
P
E
E
L
R
R
K
Dog
Lupus familis
XP_536069
769
88595
S424
L
L
P
T
Q
L
P
S
P
E
E
L
R
R
K
Cat
Felis silvestris
Mouse
Mus musculus
Q8K3R3
807
92676
S422
L
L
V
D
S
M
P
S
P
E
Q
L
R
G
K
Rat
Rattus norvegicus
Q62711
772
88948
S422
Q
L
I
D
I
M
P
S
P
E
Q
L
R
G
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001514368
738
83813
P409
M
V
N
N
F
P
S
P
E
Q
L
K
G
K
I
Chicken
Gallus gallus
Q2VRL0
637
72514
E321
K
G
R
D
S
H
G
E
T
G
E
V
S
E
E
Frog
Xenopus laevis
Q32NH8
758
87399
S422
R
I
P
V
R
L
P
S
P
D
E
L
R
G
K
Zebra Danio
Brachydanio rerio
A5D6R3
784
89362
S445
L
P
L
K
Q
L
P
S
P
E
E
L
K
G
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P13217
1095
124845
P453
H
P
L
D
P
G
L
P
L
P
P
P
C
K
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001008790
753
85559
P431
N
E
A
A
F
P
S
P
E
E
L
K
G
K
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9LY51
584
66443
L268
L
V
K
K
G
R
D
L
G
D
K
E
V
W
G
Baker's Yeast
Sacchar. cerevisiae
P32383
869
100529
E510
D
K
L
P
S
P
R
E
L
K
H
K
I
L
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.2
92.9
84.4
N.A.
71.8
72.6
N.A.
46.7
37.7
59.9
45
N.A.
25.1
N.A.
N.A.
41.3
Protein Similarity:
100
99.7
94.4
91
N.A.
81.4
84.4
N.A.
62.5
54.4
77.9
65.4
N.A.
39.6
N.A.
N.A.
58.7
P-Site Identity:
100
100
100
93.3
N.A.
53.3
53.3
N.A.
0
6.6
60
53.3
N.A.
0
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
73.3
66.6
N.A.
26.6
20
80
73.3
N.A.
6.6
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.3
24.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
40.2
43.2
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
6.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% C
% Asp:
8
0
0
29
0
0
8
0
0
15
0
0
0
0
0
% D
% Glu:
0
8
0
0
0
0
0
15
15
58
50
8
0
8
8
% E
% Phe:
0
0
0
0
15
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
8
0
0
8
8
8
0
8
8
0
0
15
29
8
% G
% His:
8
0
0
0
0
8
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
8
8
0
8
0
0
0
0
0
0
0
8
0
15
% I
% Lys:
8
8
8
15
0
0
0
0
0
8
8
22
8
22
50
% K
% Leu:
29
43
22
0
0
43
8
8
15
0
15
58
0
8
15
% L
% Met:
8
0
0
0
0
15
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
15
36
8
8
22
58
22
58
8
8
8
0
0
0
% P
% Gln:
8
0
0
0
36
0
0
0
0
8
15
0
0
0
0
% Q
% Arg:
8
0
8
0
8
8
8
0
0
0
0
0
50
29
8
% R
% Ser:
0
0
0
0
22
0
15
58
0
0
0
0
8
0
0
% S
% Thr:
0
0
0
29
0
0
0
0
8
0
0
0
0
0
0
% T
% Val:
22
15
8
8
0
0
0
0
0
0
0
8
8
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _