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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VRK1
All Species:
29.39
Human Site:
S274
Identified Species:
53.89
UniProt:
Q99986
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99986
NP_003375.1
396
45476
S274
D
P
K
Y
V
R
D
S
K
I
R
Y
R
E
N
Chimpanzee
Pan troglodytes
XP_510157
396
45456
S274
D
P
K
Y
V
R
D
S
K
I
R
Y
R
E
N
Rhesus Macaque
Macaca mulatta
XP_001102618
396
45467
S274
D
P
K
Y
V
R
D
S
K
I
R
Y
R
E
N
Dog
Lupus familis
XP_547970
395
44398
S274
D
P
N
Y
V
R
D
S
K
M
R
Y
R
E
N
Cat
Felis silvestris
Mouse
Mus musculus
Q80X41
440
49722
S274
D
P
N
Y
V
R
D
S
K
I
R
Y
R
D
N
Rat
Rattus norvegicus
P97633
325
37477
G208
R
D
D
M
E
S
L
G
Y
V
L
M
Y
F
N
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512207
479
54436
S273
D
P
N
Y
V
R
D
S
K
I
S
Y
R
E
N
Chicken
Gallus gallus
NP_001006485
413
46937
S273
D
P
N
F
V
R
D
S
K
I
R
C
R
D
N
Frog
Xenopus laevis
NP_001080108
438
49973
L263
N
P
T
A
V
Q
D
L
K
A
K
L
L
S
N
Zebra Danio
Brachydanio rerio
Q7ZUS1
425
47752
S275
D
P
L
Y
V
R
D
S
K
L
R
C
R
D
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7KRY6
599
65975
K280
P
P
K
V
Q
K
A
K
E
A
F
M
D
N
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_783182
473
53072
M267
L
T
D
L
N
Y
V
M
N
Q
K
I
K
Y
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P23292
546
62061
E295
P
N
N
K
Q
K
Y
E
K
I
G
E
K
K
R
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
98.2
83.8
N.A.
76.8
29
N.A.
66.1
70.2
47.2
59.2
N.A.
31
N.A.
N.A.
39.7
Protein Similarity:
100
99.7
98.9
88.1
N.A.
83.4
46.4
N.A.
73
81.5
59.3
72.4
N.A.
43.7
N.A.
N.A.
56
P-Site Identity:
100
100
100
86.6
N.A.
86.6
6.6
N.A.
86.6
73.3
33.3
73.3
N.A.
13.3
N.A.
N.A.
0
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
13.3
N.A.
86.6
86.6
53.3
86.6
N.A.
26.6
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
20.8
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
37.3
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
8
0
0
8
0
0
16
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
16
0
0
0
% C
% Asp:
62
8
16
0
0
0
70
0
0
0
0
0
8
24
0
% D
% Glu:
0
0
0
0
8
0
0
8
8
0
0
8
0
39
0
% E
% Phe:
0
0
0
8
0
0
0
0
0
0
8
0
0
8
0
% F
% Gly:
0
0
0
0
0
0
0
8
0
0
8
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
54
0
8
0
0
8
% I
% Lys:
0
0
31
8
0
16
0
8
77
0
16
0
16
8
0
% K
% Leu:
8
0
8
8
0
0
8
8
0
8
8
8
8
0
0
% L
% Met:
0
0
0
8
0
0
0
8
0
8
0
16
0
0
0
% M
% Asn:
8
8
39
0
8
0
0
0
8
0
0
0
0
8
77
% N
% Pro:
16
77
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
16
8
0
0
0
8
0
0
0
0
0
% Q
% Arg:
8
0
0
0
0
62
0
0
0
0
54
0
62
0
8
% R
% Ser:
0
0
0
0
0
8
0
62
0
0
8
0
0
8
8
% S
% Thr:
0
8
8
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
8
70
0
8
0
0
8
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
54
0
8
8
0
8
0
0
47
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _