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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD17B10
All Species:
16.97
Human Site:
S219
Identified Species:
33.94
UniProt:
Q99714
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.27
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99714
NP_001032900.1
261
26923
S219
K
V
C
N
F
L
A
S
Q
V
P
F
P
S
R
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001087982
261
27083
S219
K
V
R
N
F
L
A
S
Q
V
P
F
P
S
R
Dog
Lupus familis
XP_538051
261
27137
S219
K
V
R
N
F
L
A
S
Q
V
P
F
P
N
R
Cat
Felis silvestris
Mouse
Mus musculus
O08756
261
27400
S219
K
V
R
N
F
L
A
S
Q
V
P
F
P
S
R
Rat
Rattus norvegicus
O70351
261
27227
S219
K
V
R
N
F
L
A
S
Q
V
P
F
P
S
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512537
205
21655
I184
F
A
H
L
V
Q
A
I
V
E
N
P
M
L
N
Chicken
Gallus gallus
Frog
Xenopus laevis
Q6NUE2
236
25189
P198
D
S
L
N
K
M
I
P
L
G
R
F
G
E
P
Zebra Danio
Brachydanio rerio
Q6P0H7
237
24860
P199
E
A
A
V
R
T
I
P
L
G
R
F
G
E
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
O18404
255
26886
K213
K
V
R
T
F
L
A
K
S
I
P
F
P
Q
R
Honey Bee
Apis mellifera
XP_001120471
254
27081
R212
K
V
R
V
F
L
Q
R
S
V
P
F
P
K
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_780014
260
27301
R218
K
V
R
T
F
L
A
R
S
I
P
F
P
S
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P33207
319
33530
L276
E
D
M
E
K
K
I
L
G
T
I
P
L
G
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.3
91.9
N.A.
86.2
87.7
N.A.
63.2
N.A.
29.5
30.6
N.A.
67.4
60.9
N.A.
68.2
Protein Similarity:
100
N.A.
97.6
95
N.A.
93.4
94.2
N.A.
72.8
N.A.
47.8
49.8
N.A.
78.5
71.6
N.A.
79.3
P-Site Identity:
100
N.A.
93.3
86.6
N.A.
93.3
93.3
N.A.
6.6
N.A.
13.3
6.6
N.A.
60
60
N.A.
66.6
P-Site Similarity:
100
N.A.
93.3
93.3
N.A.
93.3
93.3
N.A.
6.6
N.A.
20
13.3
N.A.
66.6
60
N.A.
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
23.5
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
39.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
17
9
0
0
0
67
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
17
0
0
9
0
0
0
0
0
9
0
0
0
17
0
% E
% Phe:
9
0
0
0
67
0
0
0
0
0
0
84
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
9
17
0
0
17
9
0
% G
% His:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
25
9
0
17
9
0
0
0
0
% I
% Lys:
67
0
0
0
17
9
0
9
0
0
0
0
0
9
0
% K
% Leu:
0
0
9
9
0
67
0
9
17
0
0
0
9
9
0
% L
% Met:
0
0
9
0
0
9
0
0
0
0
0
0
9
0
0
% M
% Asn:
0
0
0
50
0
0
0
0
0
0
9
0
0
9
9
% N
% Pro:
0
0
0
0
0
0
0
17
0
0
67
17
67
0
17
% P
% Gln:
0
0
0
0
0
9
9
0
42
0
0
0
0
9
0
% Q
% Arg:
0
0
59
0
9
0
0
17
0
0
17
0
0
0
75
% R
% Ser:
0
9
0
0
0
0
0
42
25
0
0
0
0
42
0
% S
% Thr:
0
0
0
17
0
9
0
0
0
9
0
0
0
0
0
% T
% Val:
0
67
0
17
9
0
0
0
9
50
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _