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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP3K5
All Species:
22.42
Human Site:
S498
Identified Species:
49.33
UniProt:
Q99683
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99683
NP_005914.1
1374
154537
S498
H
M
R
V
I
Q
A
S
E
K
L
F
K
L
K
Chimpanzee
Pan troglodytes
XP_001171211
1375
154924
S499
H
M
R
V
I
Q
A
S
E
K
L
F
K
L
K
Rhesus Macaque
Macaca mulatta
XP_001111127
1297
143635
A461
P
T
Q
V
V
L
A
A
E
Q
L
Y
K
L
N
Dog
Lupus familis
XP_533420
1645
181128
S769
H
M
R
V
I
Q
A
S
E
K
L
F
K
L
K
Cat
Felis silvestris
Mouse
Mus musculus
O35099
1380
154441
S505
H
L
R
V
I
Q
A
S
E
K
L
F
R
L
K
Rat
Rattus norvegicus
XP_001073260
1338
150427
S469
H
L
R
V
I
Q
A
S
E
K
L
F
R
L
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511920
1243
141469
N448
P
S
Y
L
S
I
N
N
E
A
E
E
K
T
V
Chicken
Gallus gallus
XP_419725
1260
143069
L448
S
V
V
R
F
P
V
L
I
L
E
P
T
K
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001155222
1364
153160
S485
N
T
R
V
I
Q
A
S
E
K
L
F
K
I
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477089
1363
155478
A449
W
M
D
F
F
L
E
A
T
N
T
E
E
V
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001202919
1288
145042
V451
N
F
W
L
D
F
F
V
E
A
T
K
E
S
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
44.9
68
N.A.
94.1
92.7
N.A.
84.4
80.4
N.A.
71.7
N.A.
40.6
N.A.
N.A.
44.6
Protein Similarity:
100
99.4
61.3
73.1
N.A.
95.8
94.4
N.A.
87.8
87
N.A.
84.1
N.A.
58.2
N.A.
N.A.
60.7
P-Site Identity:
100
100
40
100
N.A.
86.6
86.6
N.A.
13.3
0
N.A.
80
N.A.
13.3
N.A.
N.A.
6.6
P-Site Similarity:
100
100
73.3
100
N.A.
100
100
N.A.
26.6
6.6
N.A.
93.3
N.A.
33.3
N.A.
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
64
19
0
19
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
0
10
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
10
0
82
0
19
19
19
0
0
% E
% Phe:
0
10
0
10
19
10
10
0
0
0
0
55
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
46
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
55
10
0
0
10
0
0
0
0
10
10
% I
% Lys:
0
0
0
0
0
0
0
0
0
55
0
10
55
10
64
% K
% Leu:
0
19
0
19
0
19
0
10
0
10
64
0
0
55
0
% L
% Met:
0
37
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
19
0
0
0
0
0
10
10
0
10
0
0
0
0
10
% N
% Pro:
19
0
0
0
0
10
0
0
0
0
0
10
0
0
0
% P
% Gln:
0
0
10
0
0
55
0
0
0
10
0
0
0
0
0
% Q
% Arg:
0
0
55
10
0
0
0
0
0
0
0
0
19
0
0
% R
% Ser:
10
10
0
0
10
0
0
55
0
0
0
0
0
10
0
% S
% Thr:
0
19
0
0
0
0
0
0
10
0
19
0
10
10
10
% T
% Val:
0
10
10
64
10
0
10
10
0
0
0
0
0
10
10
% V
% Trp:
10
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _