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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3C
All Species:
13.64
Human Site:
Y489
Identified Species:
23.08
UniProt:
Q99613
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99613
NP_001032897.1
913
105344
Y489
I
I
E
R
V
Q
R
Y
L
E
E
K
G
T
T
Chimpanzee
Pan troglodytes
XP_510902
575
66735
L185
Y
K
A
H
Q
R
Q
L
T
P
P
E
G
S
S
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536923
913
105495
Y489
I
I
E
R
V
Q
R
Y
L
E
E
K
G
T
T
Cat
Felis silvestris
Mouse
Mus musculus
Q8R1B4
911
105513
Y487
I
I
E
R
V
Q
R
Y
L
E
E
K
G
T
T
Rat
Rattus norvegicus
B5DFC8
911
105416
Y487
I
I
E
R
V
Q
R
Y
L
E
E
K
G
T
T
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q4QR58
926
106985
K491
E
V
I
E
R
A
Q
K
Y
L
Q
E
K
G
S
Zebra Danio
Brachydanio rerio
Q6PFQ2
926
106349
Q488
G
I
I
D
R
L
L
Q
Y
L
E
T
K
G
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A1ZAX1
910
105636
N455
S
R
L
K
D
E
V
N
V
V
K
T
I
E
L
Honey Bee
Apis mellifera
XP_623580
889
103950
Q454
E
R
L
K
D
E
K
Q
V
S
T
I
I
D
K
Nematode Worm
Caenorhab. elegans
O02328
898
103824
K447
H
S
N
D
Y
I
E
K
L
K
A
E
K
D
M
Sea Urchin
Strong. purpuratus
XP_787192
1170
135125
G663
Q
E
K
T
E
G
E
G
Q
E
K
T
D
E
S
Poplar Tree
Populus trichocarpa
XP_002323353
895
101455
L413
V
A
L
K
R
V
E
L
I
Y
Y
K
P
Q
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O49160
900
102930
E420
K
V
A
L
R
R
V
E
A
I
Y
Y
K
P
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SBD4
872
98381
A429
Y
E
H
L
R
K
D
A
S
L
E
V
P
Q
E
Conservation
Percent
Protein Identity:
100
62.4
N.A.
98.5
N.A.
96.7
96.1
N.A.
N.A.
N.A.
79.2
76.1
N.A.
53
55.8
44.4
43.9
Protein Similarity:
100
62.6
N.A.
99.4
N.A.
97.6
97.6
N.A.
N.A.
N.A.
89.5
86.2
N.A.
70
72.5
64.5
58.9
P-Site Identity:
100
6.6
N.A.
100
N.A.
100
100
N.A.
N.A.
N.A.
0
13.3
N.A.
0
0
6.6
6.6
P-Site Similarity:
100
40
N.A.
100
N.A.
100
100
N.A.
N.A.
N.A.
33.3
20
N.A.
26.6
26.6
20
26.6
Percent
Protein Identity:
37
N.A.
N.A.
35.1
N.A.
33.6
Protein Similarity:
55.2
N.A.
N.A.
53
N.A.
54
P-Site Identity:
6.6
N.A.
N.A.
0
N.A.
6.6
P-Site Similarity:
26.6
N.A.
N.A.
13.3
N.A.
13.3
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
15
0
0
8
0
8
8
0
8
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
15
15
0
8
0
0
0
0
0
8
15
0
% D
% Glu:
15
15
29
8
8
15
22
8
0
36
43
22
0
15
15
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
0
0
0
8
0
8
0
0
0
0
36
15
0
% G
% His:
8
0
8
8
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
29
36
15
0
0
8
0
0
8
8
0
8
15
0
0
% I
% Lys:
8
8
8
22
0
8
8
15
0
8
15
36
29
0
8
% K
% Leu:
0
0
22
15
0
8
8
15
36
22
0
0
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% M
% Asn:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
8
0
15
8
0
% P
% Gln:
8
0
0
0
8
29
15
15
8
0
8
0
0
15
8
% Q
% Arg:
0
15
0
29
36
15
29
0
0
0
0
0
0
0
0
% R
% Ser:
8
8
0
0
0
0
0
0
8
8
0
0
0
8
29
% S
% Thr:
0
0
0
8
0
0
0
0
8
0
8
22
0
29
29
% T
% Val:
8
15
0
0
29
8
15
0
15
8
0
8
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
15
0
0
0
8
0
0
29
15
8
15
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _