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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3C
All Species:
53.64
Human Site:
T790
Identified Species:
90.77
UniProt:
Q99613
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99613
NP_001032897.1
913
105344
T790
I
Q
E
E
S
L
R
T
Y
L
F
T
Y
S
S
Chimpanzee
Pan troglodytes
XP_510902
575
66735
Y453
Q
E
E
S
L
R
T
Y
L
F
T
Y
S
S
V
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536923
913
105495
T790
I
Q
E
E
S
L
R
T
Y
L
F
T
Y
S
S
Cat
Felis silvestris
Mouse
Mus musculus
Q8R1B4
911
105513
T788
I
Q
E
E
S
L
R
T
Y
L
F
T
Y
S
S
Rat
Rattus norvegicus
B5DFC8
911
105416
T788
I
Q
E
E
S
L
R
T
Y
L
F
T
Y
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q4QR58
926
106985
T792
I
Q
E
E
S
L
R
T
Y
L
F
T
Y
S
S
Zebra Danio
Brachydanio rerio
Q6PFQ2
926
106349
T789
I
Q
E
E
S
L
R
T
Y
L
F
T
Y
S
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A1ZAX1
910
105636
T756
I
K
E
E
S
L
R
T
Y
L
F
T
Y
S
N
Honey Bee
Apis mellifera
XP_623580
889
103950
T755
N
K
E
E
A
L
R
T
Y
L
F
T
Y
S
H
Nematode Worm
Caenorhab. elegans
O02328
898
103824
T747
I
Q
E
E
S
L
R
T
Y
L
L
T
Y
S
T
Sea Urchin
Strong. purpuratus
XP_787192
1170
135125
T963
I
Q
E
E
S
L
R
T
Y
L
F
T
Y
G
S
Poplar Tree
Populus trichocarpa
XP_002323353
895
101455
T710
I
K
E
E
A
L
R
T
H
L
F
S
Y
S
S
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O49160
900
102930
T717
I
K
E
E
A
L
R
T
Y
L
F
T
Y
S
S
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SBD4
872
98381
T728
I
Q
E
E
G
L
R
T
Y
L
F
T
Y
A
P
Conservation
Percent
Protein Identity:
100
62.4
N.A.
98.5
N.A.
96.7
96.1
N.A.
N.A.
N.A.
79.2
76.1
N.A.
53
55.8
44.4
43.9
Protein Similarity:
100
62.6
N.A.
99.4
N.A.
97.6
97.6
N.A.
N.A.
N.A.
89.5
86.2
N.A.
70
72.5
64.5
58.9
P-Site Identity:
100
13.3
N.A.
100
N.A.
100
100
N.A.
N.A.
N.A.
100
100
N.A.
86.6
73.3
86.6
93.3
P-Site Similarity:
100
20
N.A.
100
N.A.
100
100
N.A.
N.A.
N.A.
100
100
N.A.
100
86.6
93.3
93.3
Percent
Protein Identity:
37
N.A.
N.A.
35.1
N.A.
33.6
Protein Similarity:
55.2
N.A.
N.A.
53
N.A.
54
P-Site Identity:
73.3
N.A.
N.A.
86.6
N.A.
80
P-Site Similarity:
100
N.A.
N.A.
100
N.A.
86.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
22
0
0
0
0
0
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
8
100
93
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
8
86
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
0
0
0
0
0
0
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
8
% H
% Ile:
86
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
29
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
8
93
0
0
8
93
8
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% P
% Gln:
8
65
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
8
93
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
8
65
0
0
0
0
0
0
8
8
86
65
% S
% Thr:
0
0
0
0
0
0
8
93
0
0
8
86
0
0
8
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
8
86
0
0
8
93
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _