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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
EIF3C
All Species:
3.94
Human Site:
S158
Identified Species:
6.67
UniProt:
Q99613
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.31
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99613
NP_001032897.1
913
105344
S158
D
F
E
S
H
I
T
S
Y
K
Q
N
P
E
Q
Chimpanzee
Pan troglodytes
XP_510902
575
66735
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536923
913
105495
N158
D
F
E
S
H
I
T
N
Y
K
Q
N
P
E
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8R1B4
911
105513
N158
D
F
E
S
H
I
T
N
Y
K
Q
N
P
E
Q
Rat
Rattus norvegicus
B5DFC8
911
105416
N158
D
F
E
S
H
I
T
N
Y
K
Q
N
P
E
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
Frog
Xenopus laevis
Q4QR58
926
106985
A158
D
F
E
A
S
I
T
A
Y
K
Q
N
P
E
E
Zebra Danio
Brachydanio rerio
Q6PFQ2
926
106349
S158
D
F
E
T
E
I
A
S
Y
K
E
N
P
E
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
A1ZAX1
910
105636
R156
D
F
E
D
D
L
S
R
F
R
E
A
P
D
Q
Honey Bee
Apis mellifera
XP_623580
889
103950
K155
D
F
E
E
D
I
V
K
F
R
E
N
P
D
Q
Nematode Worm
Caenorhab. elegans
O02328
898
103824
K154
Q
K
L
K
K
Y
I
K
D
Q
Q
L
Q
D
L
Sea Urchin
Strong. purpuratus
XP_787192
1170
135125
K156
E
L
D
A
Q
I
T
K
Y
K
D
N
P
D
A
Poplar Tree
Populus trichocarpa
XP_002323353
895
101455
Q166
N
N
K
Q
Y
E
D
Q
I
N
K
Y
R
E
H
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O49160
900
102930
K161
L
Y
E
D
D
I
N
K
Y
R
E
A
P
E
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Q7SBD4
872
98381
D152
S
Y
I
K
A
I
A
D
L
E
D
F
M
N
E
Conservation
Percent
Protein Identity:
100
62.4
N.A.
98.5
N.A.
96.7
96.1
N.A.
N.A.
N.A.
79.2
76.1
N.A.
53
55.8
44.4
43.9
Protein Similarity:
100
62.6
N.A.
99.4
N.A.
97.6
97.6
N.A.
N.A.
N.A.
89.5
86.2
N.A.
70
72.5
64.5
58.9
P-Site Identity:
100
0
N.A.
93.3
N.A.
93.3
93.3
N.A.
N.A.
N.A.
73.3
73.3
N.A.
33.3
46.6
6.6
40
P-Site Similarity:
100
0
N.A.
100
N.A.
100
100
N.A.
N.A.
N.A.
93.3
86.6
N.A.
73.3
73.3
20
66.6
Percent
Protein Identity:
37
N.A.
N.A.
35.1
N.A.
33.6
Protein Similarity:
55.2
N.A.
N.A.
53
N.A.
54
P-Site Identity:
6.6
N.A.
N.A.
33.3
N.A.
6.6
P-Site Similarity:
33.3
N.A.
N.A.
53.3
N.A.
26.6
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
15
8
0
15
8
0
0
0
15
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
58
0
8
15
22
0
8
8
8
0
15
0
0
29
0
% D
% Glu:
8
0
65
8
8
8
0
0
0
8
29
0
0
58
15
% E
% Phe:
0
58
0
0
0
0
0
0
15
0
0
8
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
29
0
0
0
0
0
0
0
0
0
8
% H
% Ile:
0
0
8
0
0
72
8
0
8
0
0
0
0
0
0
% I
% Lys:
0
8
8
15
8
0
0
29
0
50
8
0
0
0
0
% K
% Leu:
8
8
8
0
0
8
0
0
8
0
0
8
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
8
8
0
0
0
0
8
22
0
8
0
58
0
8
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
72
0
0
% P
% Gln:
8
0
0
8
8
0
0
8
0
8
43
0
8
0
50
% Q
% Arg:
0
0
0
0
0
0
0
8
0
22
0
0
8
0
0
% R
% Ser:
8
0
0
29
8
0
8
15
0
0
0
0
0
0
0
% S
% Thr:
0
0
0
8
0
0
43
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
15
0
0
8
8
0
0
58
0
0
8
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _