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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TBX5
All Species:
44.85
Human Site:
S141
Identified Species:
82.22
UniProt:
Q99593
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99593
NP_000183.2
518
57711
S141
R
L
Y
V
H
P
D
S
P
A
T
G
A
H
W
Chimpanzee
Pan troglodytes
XP_509400
518
57702
S141
R
L
Y
V
H
P
D
S
P
A
T
G
A
H
W
Rhesus Macaque
Macaca mulatta
XP_001111737
518
57694
S141
R
L
Y
V
H
P
D
S
P
A
T
G
A
H
W
Dog
Lupus familis
XP_548568
518
57556
S141
R
L
Y
V
H
P
D
S
P
A
T
G
A
H
W
Cat
Felis silvestris
Mouse
Mus musculus
P70326
518
57813
S141
R
L
Y
V
H
P
D
S
P
A
T
G
A
H
W
Rat
Rattus norvegicus
Q5I2P1
517
57726
S141
R
L
Y
V
H
P
D
S
P
A
T
G
A
H
W
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509097
536
59706
S143
R
L
Y
V
H
P
D
S
P
A
T
G
A
H
W
Chicken
Gallus gallus
Q9PWE8
521
58384
S141
R
L
Y
V
H
P
D
S
P
A
T
G
A
H
W
Frog
Xenopus laevis
Q9W7C2
519
58062
S141
R
L
Y
V
H
P
D
S
P
A
T
G
A
H
W
Zebra Danio
Brachydanio rerio
Q9IAK8
492
55218
K119
R
Y
K
F
A
D
N
K
W
S
V
T
G
K
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24432
972
102538
S415
R
M
Y
I
H
P
D
S
P
T
T
G
E
Q
W
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q19691
423
46979
S50
F
P
P
G
P
V
G
S
P
P
E
D
D
G
V
Sea Urchin
Strong. purpuratus
XP_797010
645
70075
S224
R
L
Y
I
H
P
D
S
P
A
T
G
A
V
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.8
99.6
96.5
N.A.
96.1
95.7
N.A.
53.1
88.4
79.1
70
N.A.
22
N.A.
32.8
31.6
Protein Similarity:
100
99.8
99.8
98.2
N.A.
97.8
98
N.A.
63.6
94.4
85.7
78.9
N.A.
32.7
N.A.
48.2
43.8
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
6.6
N.A.
66.6
N.A.
13.3
86.6
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
100
100
100
20
N.A.
80
N.A.
13.3
93.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
0
0
0
0
77
0
0
77
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
8
85
0
0
0
0
8
8
0
0
% D
% Glu:
0
0
0
0
0
0
0
0
0
0
8
0
8
0
0
% E
% Phe:
8
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
8
0
0
8
0
0
0
0
85
8
8
0
% G
% His:
0
0
0
0
85
0
0
0
0
0
0
0
0
70
0
% H
% Ile:
0
0
0
16
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
8
0
0
0
0
8
0
0
0
0
0
8
0
% K
% Leu:
0
77
0
0
0
0
0
0
0
0
0
0
0
0
0
% L
% Met:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% N
% Pro:
0
8
8
0
8
85
0
0
93
8
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
8
0
% Q
% Arg:
93
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
93
0
8
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
0
0
0
0
8
85
8
0
0
0
% T
% Val:
0
0
0
70
0
8
0
0
0
0
8
0
0
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
85
% W
% Tyr:
0
8
85
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _