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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PIK3R4
All Species:
31.82
Human Site:
S614
Identified Species:
70
UniProt:
Q99570
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99570
NP_055417.1
1358
153103
S614
Y
V
G
W
Q
S
S
S
I
L
K
P
L
L
Q
Chimpanzee
Pan troglodytes
XP_516746
1358
153104
S614
Y
V
G
W
Q
S
S
S
I
L
K
P
L
L
Q
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_534260
1358
152914
S614
Y
V
G
W
Q
S
S
S
I
L
K
P
L
L
Q
Cat
Felis silvestris
Mouse
Mus musculus
Q8VD65
1358
152580
S614
Y
V
G
W
Q
S
S
S
I
L
K
P
L
L
Q
Rat
Rattus norvegicus
P0C0R5
1358
152428
S614
Y
V
G
W
Q
S
S
S
I
L
K
P
L
L
Q
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517638
1355
152495
S608
Y
V
G
W
Q
S
S
S
I
L
K
P
L
L
Q
Chicken
Gallus gallus
XP_001235241
1361
153480
S613
Y
V
G
W
Q
S
S
S
I
L
K
P
L
L
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001922676
1384
155064
S618
Y
V
G
W
Q
S
S
S
I
L
K
P
L
L
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_649868
1342
148594
D620
Y
V
G
W
Q
A
S
D
I
L
V
P
L
L
Q
Honey Bee
Apis mellifera
XP_001122289
1358
152566
P606
Y
V
G
W
H
S
S
P
I
L
M
P
L
L
Q
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P22219
1454
166341
Q657
L
G
T
V
T
L
E
Q
Y
I
L
P
L
L
I
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.9
N.A.
97.7
N.A.
95.8
95.7
N.A.
88.7
91.4
N.A.
82.3
N.A.
43.4
48
N.A.
N.A.
Protein Similarity:
100
99.9
N.A.
98.7
N.A.
97.8
97.7
N.A.
94
95.3
N.A.
89.9
N.A.
62.9
64.7
N.A.
N.A.
P-Site Identity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
N.A.
100
N.A.
80
80
N.A.
N.A.
P-Site Similarity:
100
100
N.A.
100
N.A.
100
100
N.A.
100
100
N.A.
100
N.A.
86.6
80
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
24.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
46.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
91
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
91
10
0
0
0
0
10
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
73
0
0
0
0
% K
% Leu:
10
0
0
0
0
10
0
0
0
91
10
0
100
100
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
10
0
0
0
100
0
0
0
% P
% Gln:
0
0
0
0
82
0
0
10
0
0
0
0
0
0
91
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
82
91
73
0
0
0
0
0
0
0
% S
% Thr:
0
0
10
0
10
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
91
0
10
0
0
0
0
0
0
10
0
0
0
0
% V
% Trp:
0
0
0
91
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
91
0
0
0
0
0
0
0
10
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _