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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MMP19
All Species:
13.03
Human Site:
S290
Identified Species:
26.06
UniProt:
Q99542
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q99542
NP_002420.1
508
57357
S290
S
P
M
P
D
P
C
S
S
E
L
D
A
M
M
Chimpanzee
Pan troglodytes
XP_001154045
470
52999
K257
G
I
Q
A
L
Y
G
K
K
S
P
V
I
R
D
Rhesus Macaque
Macaca mulatta
XP_001111624
508
57284
S290
S
P
M
P
D
P
C
S
G
E
L
D
A
M
M
Dog
Lupus familis
XP_848410
547
61550
S290
G
P
M
P
D
P
C
S
G
E
L
D
A
I
M
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHI0
527
59104
S290
G
P
M
P
N
P
C
S
G
E
V
D
A
M
V
Rat
Rattus norvegicus
Q99PW6
618
70447
D354
G
A
K
P
N
I
C
D
G
N
F
N
T
V
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512754
558
61524
K289
S
P
V
P
D
P
C
K
G
E
L
D
A
I
L
Chicken
Gallus gallus
XP_415771
498
56504
G285
T
H
F
Q
D
W
S
G
D
L
Y
G
E
E
H
Frog
Xenopus laevis
Q10835
469
53622
D256
R
F
V
L
P
D
D
D
V
Q
G
I
Q
V
L
Zebra Danio
Brachydanio rerio
XP_001337581
501
56922
R283
Q
L
V
G
R
A
L
R
W
T
M
Q
D
W
Q
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_393358
568
63683
S307
D
S
E
L
C
T
N
S
K
V
D
T
M
F
N
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_001028820
562
62609
Y332
D
T
R
C
K
K
T
Y
D
A
I
T
L
I
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
90.7
94.4
79.3
N.A.
76.6
32
N.A.
58.2
36.8
34.2
35.4
N.A.
N.A.
34.3
N.A.
35
Protein Similarity:
100
91.3
97.2
84
N.A.
85.3
46.7
N.A.
68.6
50.5
46.2
51.9
N.A.
N.A.
50.8
N.A.
49.8
P-Site Identity:
100
0
93.3
80
N.A.
66.6
13.3
N.A.
66.6
6.6
0
0
N.A.
N.A.
6.6
N.A.
0
P-Site Similarity:
100
0
93.3
86.6
N.A.
86.6
33.3
N.A.
86.6
13.3
26.6
13.3
N.A.
N.A.
6.6
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
9
0
9
0
0
0
9
0
0
42
0
9
% A
% Cys:
0
0
0
9
9
0
50
0
0
0
0
0
0
0
0
% C
% Asp:
17
0
0
0
42
9
9
17
17
0
9
42
9
0
9
% D
% Glu:
0
0
9
0
0
0
0
0
0
42
0
0
9
9
0
% E
% Phe:
0
9
9
0
0
0
0
0
0
0
9
0
0
9
0
% F
% Gly:
34
0
0
9
0
0
9
9
42
0
9
9
0
0
0
% G
% His:
0
9
0
0
0
0
0
0
0
0
0
0
0
0
9
% H
% Ile:
0
9
0
0
0
9
0
0
0
0
9
9
9
25
0
% I
% Lys:
0
0
9
0
9
9
0
17
17
0
0
0
0
0
0
% K
% Leu:
0
9
0
17
9
0
9
0
0
9
34
0
9
0
17
% L
% Met:
0
0
34
0
0
0
0
0
0
0
9
0
9
25
25
% M
% Asn:
0
0
0
0
17
0
9
0
0
9
0
9
0
0
9
% N
% Pro:
0
42
0
50
9
42
0
0
0
0
9
0
0
0
0
% P
% Gln:
9
0
9
9
0
0
0
0
0
9
0
9
9
0
9
% Q
% Arg:
9
0
9
0
9
0
0
9
0
0
0
0
0
9
9
% R
% Ser:
25
9
0
0
0
0
9
42
9
9
0
0
0
0
0
% S
% Thr:
9
9
0
0
0
9
9
0
0
9
0
17
9
0
0
% T
% Val:
0
0
25
0
0
0
0
0
9
9
9
9
0
17
9
% V
% Trp:
0
0
0
0
0
9
0
0
9
0
0
0
0
9
0
% W
% Tyr:
0
0
0
0
0
9
0
9
0
0
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _