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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADO All Species: 10.61
Human Site: T59 Identified Species: 17.95
UniProt: Q96SZ5 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96SZ5 NP_116193.2 270 29751 T59 S K L K S L L T Q L R A E D L
Chimpanzee Pan troglodytes XP_001161814 239 25673 A59 L R G G S X R A R R A V A G G
Rhesus Macaque Macaca mulatta XP_001092839 270 29687 T59 S K L K S L L T Q V R A E D L
Dog Lupus familis XP_546121 270 29604 T59 S K L K N L L T Q V R A E D L
Cat Felis silvestris
Mouse Mus musculus Q6PDY2 256 28354 R59 E D L N I A P R K A L P Q P L
Rat Rattus norvegicus NP_001101096 256 28430 R59 E D L N I A P R K A L P Q P L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510462 264 28452 V60 L K H L L D E V R A E D L N I
Chicken Gallus gallus
Frog Xenopus laevis NP_001088077 259 27370 F79 S C F S M G V F L L R P G A C
Zebra Danio Brachydanio rerio NP_998358 249 27467 A66 P V P H Q R I A P P V T Y M H
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648176 240 27230 S61 G S H R A P C S Y M H I F E D
Honey Bee Apis mellifera XP_001120557 231 26005 Q59 I L D F I Q V Q H A P M W V I
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_787160 257 28739 E66 P P N P A A F E A A A G G D P
Poplar Tree Populus trichocarpa XP_002325431 275 30753 M74 L C N I L D N M K P E D V G L
Maize Zea mays NP_001130184 276 30043 E85 R L S G L L N E L K P R D V R
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 67 98.5 92.9 N.A. 86.6 85.1 N.A. 65.1 N.A. 52.9 54.4 N.A. 27.4 30 N.A. 34.4
Protein Similarity: 100 70.7 98.8 96.3 N.A. 89.6 88.8 N.A. 73.3 N.A. 66.6 67.4 N.A. 45.5 47 N.A. 52.2
P-Site Identity: 100 6.6 93.3 86.6 N.A. 13.3 13.3 N.A. 6.6 N.A. 20 0 N.A. 0 0 N.A. 6.6
P-Site Similarity: 100 20 100 100 N.A. 26.6 26.6 N.A. 26.6 N.A. 26.6 6.6 N.A. 33.3 13.3 N.A. 13.3
Percent
Protein Identity: 28.3 31.5 N.A. N.A. N.A. N.A.
Protein Similarity: 44.3 45.6 N.A. N.A. N.A. N.A.
P-Site Identity: 6.6 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 13.3 13.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 15 22 0 15 8 36 15 22 8 8 0 % A
% Cys: 0 15 0 0 0 0 8 0 0 0 0 0 0 0 8 % C
% Asp: 0 15 8 0 0 15 0 0 0 0 0 15 8 29 8 % D
% Glu: 15 0 0 0 0 0 8 15 0 0 15 0 22 8 0 % E
% Phe: 0 0 8 8 0 0 8 8 0 0 0 0 8 0 0 % F
% Gly: 8 0 8 15 0 8 0 0 0 0 0 8 15 15 8 % G
% His: 0 0 15 8 0 0 0 0 8 0 8 0 0 0 8 % H
% Ile: 8 0 0 8 22 0 8 0 0 0 0 8 0 0 15 % I
% Lys: 0 29 0 22 0 0 0 0 22 8 0 0 0 0 0 % K
% Leu: 22 15 36 8 22 29 22 0 15 15 15 0 8 0 43 % L
% Met: 0 0 0 0 8 0 0 8 0 8 0 8 0 8 0 % M
% Asn: 0 0 15 15 8 0 15 0 0 0 0 0 0 8 0 % N
% Pro: 15 8 8 8 0 8 15 0 8 15 15 22 0 15 8 % P
% Gln: 0 0 0 0 8 8 0 8 22 0 0 0 15 0 0 % Q
% Arg: 8 8 0 8 0 8 8 15 15 8 29 8 0 0 8 % R
% Ser: 29 8 8 8 22 0 0 8 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 22 0 0 0 8 0 0 0 % T
% Val: 0 8 0 0 0 0 15 8 0 15 8 8 8 15 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 8 0 0 0 8 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _