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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ADO All Species: 21.82
Human Site: S235 Identified Species: 36.92
UniProt: Q96SZ5 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96SZ5 NP_116193.2 270 29751 S235 P V R P K E A S S S A C D L P
Chimpanzee Pan troglodytes XP_001161814 239 25673 S204 P V R P K E A S S S A C D L P
Rhesus Macaque Macaca mulatta XP_001092839 270 29687 S235 P V R P K E A S S S A C D L P
Dog Lupus familis XP_546121 270 29604 S235 P V R D K E A S S S A C D L P
Cat Felis silvestris
Mouse Mus musculus Q6PDY2 256 28354 S221 P I R P K E A S G S A C D L P
Rat Rattus norvegicus NP_001101096 256 28430 S221 P I K P K E A S G S A C D L P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510462 264 28452 G229 A G A D K E A G A A A A V V P
Chicken Gallus gallus
Frog Xenopus laevis NP_001088077 259 27370 N224 G P A A A S D N C A G G A A Q
Zebra Danio Brachydanio rerio NP_998358 249 27467 K214 A H S E A A D K K S E V Q D Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_648176 240 27230 P204 Q V Q L H C I P S P D T Y Y C
Honey Bee Apis mellifera XP_001120557 231 26005 C197 T V G S S E L C T D S P D I V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_787160 257 28739 L220 Y F K E L K S L Q P S S S E S
Poplar Tree Populus trichocarpa XP_002325431 275 30753 E237 A L S N G E M E L K K E E G S
Maize Zea mays NP_001130184 276 30043 M225 P C A V L D V M G P P Y N R A
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 67 98.5 92.9 N.A. 86.6 85.1 N.A. 65.1 N.A. 52.9 54.4 N.A. 27.4 30 N.A. 34.4
Protein Similarity: 100 70.7 98.8 96.3 N.A. 89.6 88.8 N.A. 73.3 N.A. 66.6 67.4 N.A. 45.5 47 N.A. 52.2
P-Site Identity: 100 100 100 93.3 N.A. 86.6 80 N.A. 33.3 N.A. 0 6.6 N.A. 13.3 20 N.A. 0
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 93.3 N.A. 53.3 N.A. 13.3 6.6 N.A. 20 40 N.A. 26.6
Percent
Protein Identity: 28.3 31.5 N.A. N.A. N.A. N.A.
Protein Similarity: 44.3 45.6 N.A. N.A. N.A. N.A.
P-Site Identity: 6.6 6.6 N.A. N.A. N.A. N.A.
P-Site Similarity: 20 20 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 22 0 22 8 15 8 50 0 8 15 50 8 8 8 8 % A
% Cys: 0 8 0 0 0 8 0 8 8 0 0 43 0 0 8 % C
% Asp: 0 0 0 15 0 8 15 0 0 8 8 0 50 8 0 % D
% Glu: 0 0 0 15 0 65 0 8 0 0 8 8 8 8 0 % E
% Phe: 0 8 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 8 8 0 8 0 0 8 22 0 8 8 0 8 0 % G
% His: 0 8 0 0 8 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 15 0 0 0 0 8 0 0 0 0 0 0 8 0 % I
% Lys: 0 0 15 0 50 8 0 8 8 8 8 0 0 0 0 % K
% Leu: 0 8 0 8 15 0 8 8 8 0 0 0 0 43 0 % L
% Met: 0 0 0 0 0 0 8 8 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 8 0 0 0 8 0 0 0 0 8 0 0 % N
% Pro: 50 8 0 36 0 0 0 8 0 22 8 8 0 0 50 % P
% Gln: 8 0 8 0 0 0 0 0 8 0 0 0 8 0 15 % Q
% Arg: 0 0 36 0 0 0 0 0 0 0 0 0 0 8 0 % R
% Ser: 0 0 15 8 8 8 8 43 36 50 15 8 8 0 15 % S
% Thr: 8 0 0 0 0 0 0 0 8 0 0 8 0 0 0 % T
% Val: 0 43 0 8 0 0 8 0 0 0 0 8 8 8 8 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 8 0 0 0 0 0 0 0 0 0 0 8 8 8 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _