KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
IWS1
All Species:
11.52
Human Site:
T435
Identified Species:
19.49
UniProt:
Q96ST2
Number Species:
13
Phosphosite Substitution
Charge Score:
0.38
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96ST2
NP_060439.2
819
91955
T435
K
S
G
K
R
E
K
T
I
A
S
D
S
E
E
Chimpanzee
Pan troglodytes
XP_001139705
1089
121835
T705
K
S
G
K
R
E
K
T
I
A
S
D
S
E
E
Rhesus Macaque
Macaca mulatta
XP_001087787
827
93220
T435
K
S
G
K
R
E
K
T
I
A
S
D
S
E
E
Dog
Lupus familis
XP_533312
832
93567
L448
S
G
K
R
E
K
T
L
A
S
D
S
E
E
E
Cat
Felis silvestris
Mouse
Mus musculus
Q8C1D8
766
85230
E415
S
D
S
E
S
G
N
E
E
E
N
L
I
A
D
Rat
Rattus norvegicus
Q3SWT4
764
85429
G412
F
G
S
D
S
E
S
G
N
E
E
E
N
L
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510535
927
102715
A542
S
D
Q
R
N
K
K
A
I
A
S
D
S
E
V
Chicken
Gallus gallus
XP_422571
689
77823
E338
S
D
S
E
S
G
N
E
Q
E
N
L
I
A
D
Frog
Xenopus laevis
Q6DE96
836
92684
D452
K
K
K
S
A
S
S
D
S
E
E
E
D
E
R
Zebra Danio
Brachydanio rerio
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_001097000
820
90557
S438
G
S
R
S
R
S
R
S
I
S
G
G
S
R
K
Honey Bee
Apis mellifera
XP_624549
770
87091
E419
R
V
L
S
D
S
E
E
E
D
G
V
K
A
T
Nematode Worm
Caenorhab. elegans
Q19375
511
57235
P160
D
D
D
D
E
D
R
P
K
K
T
N
D
L
D
Sea Urchin
Strong. purpuratus
XP_798740
798
90991
E430
F
E
G
F
G
A
A
E
L
Q
G
P
A
K
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Q06505
410
46064
N59
N
D
T
K
D
P
D
N
G
E
K
N
E
E
A
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
74.7
94.3
93.8
N.A.
84.7
82.4
N.A.
69.6
65
60.4
N.A.
N.A.
26.5
30.1
22.7
31.5
Protein Similarity:
100
74.8
96.1
95.3
N.A.
88.4
87.1
N.A.
75.8
73.7
72.9
N.A.
N.A.
46.7
48.8
37.3
50.9
P-Site Identity:
100
100
100
13.3
N.A.
0
6.6
N.A.
46.6
0
13.3
N.A.
N.A.
26.6
0
0
6.6
P-Site Similarity:
100
100
100
33.3
N.A.
20
20
N.A.
60
20
20
N.A.
N.A.
53.3
13.3
33.3
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
21.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
32.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
8
8
8
8
8
29
0
0
8
22
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
36
8
15
15
8
8
8
0
8
8
29
15
0
22
% D
% Glu:
0
8
0
15
15
29
8
29
15
36
15
15
15
50
29
% E
% Phe:
15
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
15
29
0
8
15
0
8
8
0
22
8
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
36
0
0
0
15
0
8
% I
% Lys:
29
8
15
29
0
15
29
0
8
8
8
0
8
8
15
% K
% Leu:
0
0
8
0
0
0
0
8
8
0
0
15
0
15
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
8
0
15
8
8
0
15
15
8
0
0
% N
% Pro:
0
0
0
0
0
8
0
8
0
0
0
8
0
0
0
% P
% Gln:
0
0
8
0
0
0
0
0
8
8
0
0
0
0
0
% Q
% Arg:
8
0
8
15
29
0
15
0
0
0
0
0
0
8
8
% R
% Ser:
29
29
22
22
22
22
15
8
8
15
29
8
36
0
0
% S
% Thr:
0
0
8
0
0
0
8
22
0
0
8
0
0
0
8
% T
% Val:
0
8
0
0
0
0
0
0
0
0
0
8
0
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _