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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
VPS35
All Species:
22.42
Human Site:
T278
Identified Species:
54.81
UniProt:
Q96QK1
Number Species:
9
Phosphosite Substitution
Charge Score:
0.22
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96QK1
NP_060676.2
796
91707
T278
P
D
E
F
H
L
Q
T
L
N
P
F
L
R
A
Chimpanzee
Pan troglodytes
XP_001161357
757
87158
E274
L
A
L
F
A
H
R
E
D
G
P
G
I
P
A
Rhesus Macaque
Macaca mulatta
XP_001108828
723
82177
Y246
C
Y
P
D
R
V
D
Y
V
D
K
V
L
E
T
Dog
Lupus familis
XP_532570
729
83927
E246
L
A
L
F
A
H
R
E
D
G
P
G
I
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9EQH3
796
91694
T278
P
D
E
F
H
L
Q
T
L
N
P
F
L
R
A
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001520331
455
52644
A21
L
L
D
E
A
I
Q
A
V
K
V
Q
S
F
Q
Chicken
Gallus gallus
Frog
Xenopus laevis
NP_001089981
796
91412
T278
P
D
E
F
H
L
Q
T
L
N
P
F
L
R
A
Zebra Danio
Brachydanio rerio
NP_001020688
831
95262
T313
P
D
E
F
H
L
Q
T
L
N
P
F
L
R
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_392327
805
92283
T277
P
D
E
F
H
L
Q
T
L
N
A
F
L
K
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P34110
944
109124
T259
A
D
E
F
H
L
K
T
L
D
T
L
L
Q
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
95
84.6
91.3
N.A.
99.3
N.A.
N.A.
56.5
N.A.
94.5
90
N.A.
N.A.
69
N.A.
N.A.
Protein Similarity:
100
95
84.6
91.5
N.A.
99.8
N.A.
N.A.
57.1
N.A.
97.6
93.6
N.A.
N.A.
83.9
N.A.
N.A.
P-Site Identity:
100
20
6.6
20
N.A.
100
N.A.
N.A.
6.6
N.A.
100
93.3
N.A.
N.A.
80
N.A.
N.A.
P-Site Similarity:
100
33.3
26.6
33.3
N.A.
100
N.A.
N.A.
26.6
N.A.
100
100
N.A.
N.A.
93.3
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
33.6
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
52
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
53.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
73.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
20
0
0
30
0
0
10
0
0
10
0
0
0
50
% A
% Cys:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
60
10
10
0
0
10
0
20
20
0
0
0
0
0
% D
% Glu:
0
0
60
10
0
0
0
20
0
0
0
0
0
10
0
% E
% Phe:
0
0
0
80
0
0
0
0
0
0
0
50
0
10
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
20
0
20
0
0
0
% G
% His:
0
0
0
0
60
20
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
10
0
0
0
0
0
0
20
0
0
% I
% Lys:
0
0
0
0
0
0
10
0
0
10
10
0
0
10
0
% K
% Leu:
30
10
20
0
0
60
0
0
60
0
0
10
70
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
50
0
0
0
0
0
% N
% Pro:
50
0
10
0
0
0
0
0
0
0
60
0
0
20
0
% P
% Gln:
0
0
0
0
0
0
60
0
0
0
0
10
0
10
10
% Q
% Arg:
0
0
0
0
10
0
20
0
0
0
0
0
0
40
0
% R
% Ser:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
20
% S
% Thr:
0
0
0
0
0
0
0
60
0
0
10
0
0
0
20
% T
% Val:
0
0
0
0
0
10
0
0
20
0
10
10
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
0
0
10
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _