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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: NEDD4L All Species: 23.64
Human Site: S233 Identified Species: 43.33
UniProt: Q96PU5 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.17
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q96PU5 NP_001138436.1 975 111932 S233 L M D V S S E S D N N I R Q I
Chimpanzee Pan troglodytes XP_001140254 911 104904 S233 L M D V S S E S D N N I R Q I
Rhesus Macaque Macaca mulatta XP_001088661 1010 115306 S268 L M D V S S E S D N N I R Q I
Dog Lupus familis XP_533393 1027 117927 S285 L M D V S S E S D S N I R Q I
Cat Felis silvestris
Mouse Mus musculus Q8CFI0 1004 115400 S261 L M D V S S E S D N N I R Q I
Rat Rattus norvegicus Q62940 887 102376 V229 E L E P G W V V L D Q P D A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511197 1255 141275 G374 V R E K S P E G R S S I S V R
Chicken Gallus gallus XP_424462 1045 119140 S303 L I D V G S D S D N N I R Q I
Frog Xenopus laevis Q2TAS2 751 86306 R114 L K D T G Y Q R L D L C K L G
Zebra Danio Brachydanio rerio A9JRZ0 765 87445 V128 G P N D S D T V R G Q I V V S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VVI3 1007 114856 W274 H T A R T T Q W D R P T V L N
Honey Bee Apis mellifera XP_395191 782 90150 R144 R P R S Q R S R V K G T L E V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P39940 809 91798 S172 T N G H S T S S T R N H S T S
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93.4 92.4 90.8 N.A. 94.3 48 N.A. 43.9 85.6 34.1 34.3 N.A. 47.2 49.4 N.A. N.A.
Protein Similarity: 100 93.4 93.7 92.2 N.A. 95.6 60 N.A. 54 88.4 49 49.5 N.A. 61.8 61.1 N.A. N.A.
P-Site Identity: 100 100 100 93.3 N.A. 100 0 N.A. 20 80 13.3 13.3 N.A. 6.6 0 N.A. N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 20 N.A. 46.6 93.3 33.3 20 N.A. 26.6 13.3 N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 37 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 52.9 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 20 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 0 0 0 0 0 0 0 8 8 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 8 0 0 0 % C
% Asp: 0 0 54 8 0 8 8 0 54 16 0 0 8 0 0 % D
% Glu: 8 0 16 0 0 0 47 0 0 0 0 0 0 8 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 8 0 8 0 24 0 0 8 0 8 8 0 0 0 8 % G
% His: 8 0 0 8 0 0 0 0 0 0 0 8 0 0 0 % H
% Ile: 0 8 0 0 0 0 0 0 0 0 0 62 0 0 47 % I
% Lys: 0 8 0 8 0 0 0 0 0 8 0 0 8 0 0 % K
% Leu: 54 8 0 0 0 0 0 0 16 0 8 0 8 16 0 % L
% Met: 0 39 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 8 8 0 0 0 0 0 0 39 54 0 0 0 8 % N
% Pro: 0 16 0 8 0 8 0 0 0 0 8 8 0 0 0 % P
% Gln: 0 0 0 0 8 0 16 0 0 0 16 0 0 47 0 % Q
% Arg: 8 8 8 8 0 8 0 16 16 16 0 0 47 0 8 % R
% Ser: 0 0 0 8 62 47 16 54 0 16 8 0 16 0 16 % S
% Thr: 8 8 0 8 8 16 8 0 8 0 0 16 0 8 0 % T
% Val: 8 0 0 47 0 0 8 16 8 0 0 0 16 16 8 % V
% Trp: 0 0 0 0 0 8 0 8 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _