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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
COG8
All Species:
19.39
Human Site:
Y397
Identified Species:
32.82
UniProt:
Q96MW5
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96MW5
NP_115758.3
612
68424
Y397
F
Q
E
E
M
N
S
Y
M
L
I
S
A
P
A
Chimpanzee
Pan troglodytes
XP_511064
394
44531
P229
D
F
R
G
Q
L
A
P
V
F
Q
R
V
A
I
Rhesus Macaque
Macaca mulatta
XP_001100394
487
54500
N322
N
N
I
L
V
A
F
N
D
L
R
L
C
C
P
Dog
Lupus familis
XP_546857
624
69140
Y399
F
Q
D
E
M
N
S
Y
T
L
I
S
A
P
A
Cat
Felis silvestris
Mouse
Mus musculus
Q9JJA2
640
71600
Y403
F
Q
D
E
M
T
S
Y
T
L
I
S
T
A
A
Rat
Rattus norvegicus
NP_001099652
634
70744
Y403
F
Q
D
E
M
T
S
Y
T
L
I
S
A
A
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510195
500
55836
A334
L
R
L
C
C
P
V
A
L
A
Q
D
V
T
V
Chicken
Gallus gallus
XP_001232975
677
74631
A387
P
A
V
L
G
S
A
A
A
V
P
V
P
S
A
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001013524
634
71570
Y379
F
Q
E
D
M
N
L
Y
T
L
I
S
L
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VKH0
570
64891
F388
F
E
R
E
L
E
R
F
T
L
I
N
K
V
A
Honey Bee
Apis mellifera
XP_623492
605
69076
T387
T
N
V
K
M
T
T
T
I
K
S
E
N
P
P
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_001204069
378
43256
R213
R
I
K
F
L
Q
A
R
D
A
W
F
Q
G
I
Poplar Tree
Populus trichocarpa
XP_002308543
575
64166
Y399
E
D
V
T
P
P
S
Y
L
M
E
H
P
P
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_568256
569
63034
Y399
D
D
V
T
P
P
S
Y
L
M
E
H
P
P
L
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
63.7
76.9
86.5
N.A.
86
87.6
N.A.
65.3
63.2
N.A.
67
N.A.
41.5
40.6
N.A.
41.1
Protein Similarity:
100
64.2
77.7
90.3
N.A.
89
91
N.A.
70.7
71.7
N.A.
78.7
N.A.
59.1
62
N.A.
51.1
P-Site Identity:
100
0
6.6
86.6
N.A.
66.6
73.3
N.A.
0
6.6
N.A.
66.6
N.A.
33.3
13.3
N.A.
0
P-Site Similarity:
100
13.3
13.3
93.3
N.A.
73.3
80
N.A.
13.3
26.6
N.A.
80
N.A.
60
33.3
N.A.
20
Percent
Protein Identity:
32.3
N.A.
N.A.
32
N.A.
N.A.
Protein Similarity:
49.6
N.A.
N.A.
49.6
N.A.
N.A.
P-Site Identity:
20
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
33.3
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
0
0
8
22
15
8
15
0
0
22
22
43
% A
% Cys:
0
0
0
8
8
0
0
0
0
0
0
0
8
8
0
% C
% Asp:
15
15
22
8
0
0
0
0
15
0
0
8
0
0
0
% D
% Glu:
8
8
15
36
0
8
0
0
0
0
15
8
0
0
0
% E
% Phe:
43
8
0
8
0
0
8
8
0
8
0
8
0
0
0
% F
% Gly:
0
0
0
8
8
0
0
0
0
0
0
0
0
8
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
15
0
0
0
% H
% Ile:
0
8
8
0
0
0
0
0
8
0
43
0
0
0
15
% I
% Lys:
0
0
8
8
0
0
0
0
0
8
0
0
8
0
0
% K
% Leu:
8
0
8
15
15
8
8
0
22
50
0
8
8
0
15
% L
% Met:
0
0
0
0
43
0
0
0
8
15
0
0
0
0
0
% M
% Asn:
8
15
0
0
0
22
0
8
0
0
0
8
8
0
0
% N
% Pro:
8
0
0
0
15
22
0
8
0
0
8
0
22
43
15
% P
% Gln:
0
36
0
0
8
8
0
0
0
0
15
0
8
0
0
% Q
% Arg:
8
8
15
0
0
0
8
8
0
0
8
8
0
0
0
% R
% Ser:
0
0
0
0
0
8
43
0
0
0
8
36
0
8
8
% S
% Thr:
8
0
0
15
0
22
8
8
36
0
0
0
8
8
0
% T
% Val:
0
0
29
0
8
0
8
0
8
8
0
8
15
8
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
8
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _