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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HES6
All Species:
11.82
Human Site:
S139
Identified Species:
26
UniProt:
Q96HZ4
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q96HZ4
NP_001136325.1
224
24129
S139
S
M
P
L
R
E
G
S
S
F
Q
D
L
L
G
Chimpanzee
Pan troglodytes
XP_001162539
274
28840
M147
C
M
T
Q
I
N
A
M
T
Y
P
G
Q
P
H
Rhesus Macaque
Macaca mulatta
XP_001095056
150
16253
V71
A
E
V
L
E
L
T
V
R
R
V
Q
G
V
L
Dog
Lupus familis
XP_849016
234
24827
S149
S
M
P
L
R
E
G
S
S
F
R
D
L
L
G
Cat
Felis silvestris
Mouse
Mus musculus
Q9JHE6
224
24436
S139
S
M
P
L
R
E
G
S
S
F
Q
D
L
L
G
Rat
Rattus norvegicus
Q04666
281
29603
M153
C
M
T
Q
I
N
A
M
T
Y
P
G
Q
A
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506283
261
28732
S177
S
M
P
L
N
E
G
S
F
Q
D
L
L
V
D
Chicken
Gallus gallus
O57337
290
31053
M154
C
L
G
Q
I
V
A
M
N
Y
L
P
P
P
P
Frog
Xenopus laevis
Q90VV1
277
29807
M153
C
L
G
Q
I
V
A
M
N
Y
Q
Q
P
P
S
Zebra Danio
Brachydanio rerio
Q8AXV6
317
33920
E165
N
S
Y
A
S
Q
R
E
A
H
S
G
L
G
H
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q26263
435
46532
I159
C
A
N
S
L
E
Q
I
G
S
M
S
N
F
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
29.2
64.2
69.2
N.A.
85.7
29.1
N.A.
52.8
31
29.9
25.2
N.A.
22.9
N.A.
N.A.
N.A.
Protein Similarity:
100
44.8
64.7
76.5
N.A.
90.1
44.4
N.A.
63.2
45.8
45.8
39.7
N.A.
32.6
N.A.
N.A.
N.A.
P-Site Identity:
100
6.6
6.6
93.3
N.A.
100
6.6
N.A.
53.3
0
6.6
6.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
20
20
100
N.A.
100
20
N.A.
60
20
26.6
26.6
N.A.
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
0
10
0
0
37
0
10
0
0
0
0
10
0
% A
% Cys:
46
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
10
28
0
0
10
% D
% Glu:
0
10
0
0
10
46
0
10
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
10
28
0
0
0
10
0
% F
% Gly:
0
0
19
0
0
0
37
0
10
0
0
28
10
10
28
% G
% His:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
28
% H
% Ile:
0
0
0
0
37
0
0
10
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
0
19
0
46
10
10
0
0
0
0
10
10
46
28
10
% L
% Met:
0
55
0
0
0
0
0
37
0
0
10
0
0
0
0
% M
% Asn:
10
0
10
0
10
19
0
0
19
0
0
0
10
0
0
% N
% Pro:
0
0
37
0
0
0
0
0
0
0
19
10
19
28
10
% P
% Gln:
0
0
0
37
0
10
10
0
0
10
28
19
19
0
0
% Q
% Arg:
0
0
0
0
28
0
10
0
10
10
10
0
0
0
0
% R
% Ser:
37
10
0
10
10
0
0
37
28
10
10
10
0
0
19
% S
% Thr:
0
0
19
0
0
0
10
0
19
0
0
0
0
0
0
% T
% Val:
0
0
10
0
0
19
0
10
0
0
10
0
0
19
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
0
0
37
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _